β-Glucuronidase (β-G, EC 3.2.1.31) reverses phase II glucuronidation, and microbial β-G at the gut-liver interface reactivates biliary and circulating conjugates, closing enterohepatic loops for drugs, estrogens, bile acids, and bilirubin. …
Endometriosis is a challenging gynaecological condition that can lead to infertility. This unique narrative review summarises the impact of endometriosis, focusing on oocyte quality, its subcellular and molecular mechanisms, clinical …
Endometriosis may contribute to the onset of pelvic floor dysfunction (PFD) but data on urologic and bowel symptoms in endometriosis patients are scant. The aim of this study is to …
To systematically assess the prevalence of sexual dysfunction among patients suffering from endometriosis.
Endometriosis (EM) is a chronic, inflammatory gynaecological disorder defined by the presence of endometrial-like tissue outside the uterine cavity, most frequently affecting the ovaries, peritoneum, and uterosacral ligaments. Despite its …
Body image disturbance is a commonly experienced psychological impact of endometriosis and other chronic pelvic pain (CPP) conditions (e.g., vulvodynia). This systematic review and meta-analysis of quantitative literature aimed to …
Daughters of women with endometriosis are known to be at increased risk of developing this disease. Using a mouse model, we demonstrate uterine dysfunction reminiscent of endometriosis patients can also …
Does the endometrium of oligo-ovulatory women with polyendocrine metabolic ovarian syndrome (PMOS) exhibit menstrual cycle phase-specific transcriptomic alterations compared to women without PMOS?
Oocyte quality is the primary determinant of success in assisted reproductive technologies (ART), and mitochondrial dysfunction is increasingly recognized as a central mediator of poor oocyte competence across advanced maternal …
Ovarian endometriomas are commonly assessed according to cyst size and laterality, anatomical features that have long been regarded as indicators of disease severity and potential ovarian compromise. Consequently, these characteristics …