Therapeutic Potential of Linalool in Endometriosis: Modulation of Oxidative Stress, Inflammation, and Apoptosis in a Rat Model.
Endometriosis (EMS) is a chronic inflammatory disease affecting 10%-15% of women of reproductive age and is a major cause of infertility. This study explores the therapeutic effects of linalool, a …
β-Glucuronidase at the gut-liver interface: Structural selectivity, enterohepatic reactivation, and the pharmacomicrobiomic case for precision inhibition.
β-Glucuronidase (β-G, EC 3.2.1.31) reverses phase II glucuronidation, and microbial β-G at the gut-liver interface reactivates biliary and circulating conjugates, closing enterohepatic loops for drugs, estrogens, bile acids, and bilirubin. …
SEMA3C Promotes the Progression of Endometriosis by Inducing Ferroptosis and Enhancing the Viability and Migration of Endometrial Stromal Cells.
Endometriosis (EMs) is a chronic inflammatory disorder involving ectopic endometrial-like tissue. Semaphorin 3C (SEMA3C), a secreted guidance protein regulating cell survival, migration, and tissue remodeling, may contribute to EMs. This …
From polygenic risk to functional genomics: a framework for precision gynecological disease modeling.
Gynecological conditions including endometriosis, polyendocrine metabolic ovarian syndrome and malignancies cause widespread chronic morbidity and infertility, yet translating genetic discoveries into biological mechanisms remains challenging. We propose a framework integrating …
A comparative analysis of the pregnancy outcomes of IVF-ET in postoperative infertile patients with endometriosis treated with platelet-rich plasma and G-CSF: A retrospective cohort study.
This study aimed to investigate the impacts of granulocyte colony-stimulating factor (G-CSF) and platelet-rich plasma (PRP) on the pregnancy outcomes of infertile individuals with endometriosis after in vitro fertilization and …