Latest Articles

Compartment-specific inflammation-metabolism remodeling across eutopic and ectopic endometriosis tissues with cross-context evaluation in TCGA-UCEC.

Endometriosis exhibits tissue- and cell-compartment heterogeneity in inflammatory and metabolic activity. We evaluated compartment-specific remodeling in primary endometriosis tissues and used TCGA-UCEC as an independent cancer comparison.

Inflammation-Targeted Endometriosis Research Needs Pain, Mood, and Fertility-Priority Outcomes.

Endometriosis Pain: Genes linked to Inflammation Distinguish Symptomatic from Asymptomatic Disease.

Endometriosis is a multifaceted disease, causing debilitating pelvic pain in some patients, while being completely asymptomatic in others. The pathophysiology of endometriosis pain is not well understood and poorly correlated …

Therapeutic Potential of Linalool in Endometriosis: Modulation of Oxidative Stress, Inflammation, and Apoptosis in a Rat Model.

Endometriosis (EMS) is a chronic inflammatory disease affecting 10%-15% of women of reproductive age and is a major cause of infertility. This study explores the therapeutic effects of linalool, a …

Research Progress of Histone Deacetylase and Its Inhibitors in Endometriosis.

Endometriosis is a complex chronic inflammatory disease with an unclear etiology and limited treatment options, severely affecting the reproductive health and quality of life of many women. Histone deacetylases (HDACs), …

Immune regulatory networks and gut microbiota-associated targets in endometriosis: an integrative multi-omics and network analysis.

Endometriosis is an estrogen-dependent disorder characterized by chronic inflammation, immune dysregulation, and altered hormone metabolism. Although gut microbiota-derived metabolites have been implicated in shaping immune microenvironments and lesion development, the …

Evaluation of angiopoietin-like protein 4 levels in patients with endometriosis.

Endometriosis is a chronic inflammatory disorder lacking definitive laboratory diagnostic markers. Angiopoietin-like protein-4 (ANGPTL4) is a protein involved in the regulation of angiogenesis and inflammation. The aim of the present …

Elevated Neutrophil Count as a Causal Risk Factor for Endometriosis: A Mendelian Randomization Study.

Endometriosis is a chronic inflammatory gynecological disorder where immune dysregulation plays a central role in its pathogenesis. While previous observational studies have reported associations between circulating blood cell counts and …

Oocyte quality in endometriosis-associated infertility: a narrative analysis of mechanisms and therapeutic options.

Endometriosis is a challenging gynaecological condition that can lead to infertility. This unique narrative review summarises the impact of endometriosis, focusing on oocyte quality, its subcellular and molecular mechanisms, clinical …

2-Deoxyglucose Dendrimer-Enabled Niclosamide Delivery to FRβ-Expressing Macrophages Alleviates Endometriosis Progression and Associated Hyperalgesia.

Endometriosis (EuE) is a chronic, incurable disease. Due to limited efficacy, high recurrence rates, and serious side effects of current treatments, development of new, targeted, nonhormonal therapies is urgently needed. …