Endometriosis is a prevalent chronic gynecological condition affecting women of reproductive age, characterized by ectopic endometrial-like tissue growth. Despite its significant impact on quality of life, fertility, and healthcare utilization, …
The Colony-Stimulating Factor 3 Receptor (CSF3R), the receptor for granulocyte colony-stimulating factor (G-CSF), has expanded from a hematopoietic regulator to a multifunctional signalling molecule with significant relevance in gynaecological biology. …
Per- and polyfluoroalkyl substances (PFAS) accumulate in reproductive tissues, yet most studies rely on serum measurements. It remains unclear whether serum concentrations adequately reflect levels in target tissues. We evaluated …
Endometrial stromal sarcoma (ESS) is an extremely uncommon uterine malignancy, and commonly arises from preexisting endometriosis. On rare occasions, ESS arises from extrauterine tissues and is known as extra-uterine ESS. …
Decidualization of endometrial stromal cells involves significant morphological and functional changes in which alpha-smooth muscle actin (αSMA) expression decreases. Meflin, a glycosylphosphatidylinositol-anchored protein, suppresses αSMA expression and inhibits fibrosis in …
Endometriosis is a prevalent inflammatory condition characterised by the presence of endometrial-like tissue outside the uterus and is associated with significant challenges, including diagnostic delays and continued reliance on laparoscopy. …
The endometrium is a highly dynamic and complex tissue lining the uterus, playing a central role in reproductive health. Despite its importance, the pathogenesis of many benign endometrial disorders remains …
Reproductive disorders such as endometriosis and polycystic ovary syndrome (PCOS) are increasingly recognized as immune-mediated conditions, yet their immunopathology remains poorly understood. Menstrual blood, a noninvasive and biologically relevant sample, …
Whether endometriosis is a progressive disease remains debated. Central to this debate is understanding the natural history of endometriotic lesions, which are essentially wounds undergoing repeated tissue injury and repair. …