Efficacy of probiotic supplementation in reducing primary dysmenorrhea: a double-blinded randomized controlled trial.
Primary dysmenorrhea is painful menstruation in the absence of pelvic pathology, whereas secondary dysmenorrhea is menstrual pain attributable to an underlying pelvic disease (e.g., endometriosis). Nonsteroidal anti-inflammatory drugs (NSAIDs) are …
Metabolomics Analysis Reveals Gut Microbiota-Associated Sakuranin Modulates Endometrial Stem Cell Differentiation and Inflammation to Alleviate Pain in Endometriosis [Letter].
Systems-level actions of luteolin in female reproductive disorders: from molecular mechanisms to clinical translation.
Female reproductive disorders represent a major global health challenge. Despite their clinical heterogeneity, these conditions share core pathological mechanisms including oxidative stress, chronic inflammation, hormonal imbalance, metabolic dysfunction, extracellular matrix …
The role of gut microbiota in modulating estrogen in the inflammatory milieu of endometriosis: A molecular and pathophysiological perspective.
Endometriosis is a prevalent estrogen-dependent chronic inflammatory condition that affects millions of women of reproductive age worldwide. It is characterized by the growth of endometrial tissue outside the uterine cavity, …
Dietary Fiber in Endometriosis: Mechanisms, Evidence, and Potential Clinical Benefits-Up-to-Date Review.
Background: Endometriosis is a chronic, estrogen-dependent inflammatory disorder. It is associated with hormonal dysregulation, pelvic pain, and a reduced quality of life. Dietary factors may influence disease development and symptom …
The role of probiotics in the treatment of endometriosis (ProMetrioS): a randomized double-blinded placebo-controlled cross-over trial.
ProMetrioS is a randomized, blinded, placebo-controlled cross-over trial investigating the effect of a specific multispecies probiotic in patients with endometriosis. The aim of this clinical trial is to determine whether …