Latest Articles

Therapeutic Potential of Linalool in Endometriosis: Modulation of Oxidative Stress, Inflammation, and Apoptosis in a Rat Model.

Endometriosis (EMS) is a chronic inflammatory disease affecting 10%-15% of women of reproductive age and is a major cause of infertility. This study explores the therapeutic effects of linalool, a …

β-Glucuronidase at the gut-liver interface: Structural selectivity, enterohepatic reactivation, and the pharmacomicrobiomic case for precision inhibition.

β-Glucuronidase (β-G, EC 3.2.1.31) reverses phase II glucuronidation, and microbial β-G at the gut-liver interface reactivates biliary and circulating conjugates, closing enterohepatic loops for drugs, estrogens, bile acids, and bilirubin. …

SEMA3C Promotes the Progression of Endometriosis by Inducing Ferroptosis and Enhancing the Viability and Migration of Endometrial Stromal Cells.

Endometriosis (EMs) is a chronic inflammatory disorder involving ectopic endometrial-like tissue. Semaphorin 3C (SEMA3C), a secreted guidance protein regulating cell survival, migration, and tissue remodeling, may contribute to EMs. This …

Human peritoneal hypoxia may stabilize rather than initiate endometriotic lesions.

From polygenic risk to functional genomics: a framework for precision gynecological disease modeling.

Gynecological conditions including endometriosis, polyendocrine metabolic ovarian syndrome and malignancies cause widespread chronic morbidity and infertility, yet translating genetic discoveries into biological mechanisms remains challenging. We propose a framework integrating …

A comparative analysis of the pregnancy outcomes of IVF-ET in postoperative infertile patients with endometriosis treated with platelet-rich plasma and G-CSF: A retrospective cohort study.

This study aimed to investigate the impacts of granulocyte colony-stimulating factor (G-CSF) and platelet-rich plasma (PRP) on the pregnancy outcomes of infertile individuals with endometriosis after in vitro fertilization and …

Endometriosis-derived iPSCs reveal conserved stromal maturation and endocrine responsiveness.

Endometriosis is a chronic, hormone-dependent disease characterized by altered endometrial stromal function, but mechanistic and translational studies have been hindered by the lack of tractable human models. Here, we establish …

Phenotypic Analysis of Human and Murine Endometrial Organoids using a Machine Learning Approach.

Endometrial organoids are a powerful, 3D in vitro system for studying reproductive function and disease since they are more physiologically representative than 2D cell models. However, optimal methods for the …

Clinical Impact of HPV Self-Sampling and Molecular Biomarkers on Cervical Cancer Screening and Triage: "The Times They Are A-Changin'"-A Comprehensive Review and Future Perspectives.

Human papillomavirus (HPV) infection is a necessary but insufficient cause of cervical cancer (CC) and reflects a long-standing host-virus equilibrium shaped by immune control, viral persistence, and latency. The transition …

Adipose Stem Cell Mitochondrial Transplantation in ART: From Biological Rationale to Clinical Milestone.

Oocyte quality is the primary determinant of success in assisted reproductive technologies (ART), and mitochondrial dysfunction is increasingly recognized as a central mediator of poor oocyte competence across advanced maternal …