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ADVANTAGE: Advanced discovery of visceral analgesics by neuroimmune targets and the genetics of extreme human phenotype, a study protocol.

Chronic visceral pain affects over 20% of adults globally but remains poorly understood, significantly impacting quality of life and healthcare costs. Limited understanding and diagnostic misconceptions hinder effective management, particularly …

Published: May 21, 2026, midnight
Challenging the paradigm that neonatal uterine bleeding represents the first menstrual episode.

Neonatal uterine bleeding (NUB) has been hypothesized as a relatively common early-life event potentially linked to the later development of endometriosis through retrograde menstruation. However, its true prevalence and biological …

Published: May 18, 2026, midnight
Predicting superficial peritoneal endometriosis in symptomatic women with negative examination and imaging.

To develop a predictive risk score for superficial peritoneal endometriosis (SPE) in patients with negative examination and imaging based on symptoms and quality of life measures DESIGN: Multicenter nested case-control …

Published: May 18, 2026, midnight
Symptom Burden in Adenomyosis: A Comparative Analysis With Peritoneal and Deep Infiltrating Endometriosis.

Adenomyosis frequently coexists with endometriosis and shares overlapping symptoms; however, the symptom burden of isolated adenomyosis remains insufficiently defined. The aim of this study was to compare the severity and …

Published: April 30, 2026, midnight
Translation, cultural adaptation, and validation of the Portuguese version of ENDOPAIN-4D questionnaire.

The endometriosis painful symptoms-4 dimensions ENDOPAIN-4D is a multidimensional questionnaire designed to assess endometriosis-related pain. This study aimed to translate, culturally adapt, and validate ENDOPAIN-4D for European Portuguese.

Published: March 12, 2026, midnight
The value of a non-invasive bladder sensitivity paradigm in chronic pelvic pain.

We explore bladder sensitivity profiles in females with chronic pelvic pain, using a non-invasive bladder sensitivity paradigm. We aim to determine how profiles differ between groups defined by symptoms; groups …

Published: Feb. 18, 2026, midnight
Systematic Review of the Lived Experiences of Women Participating in Therapeutic Yoga.

No study has synthesized qualitative insights related to yoga across various women's health concerns, including breast and ovarian cancer, endometriosis, menopause, and pregnancy, despite numerous individual studies. The present review …

Published: Feb. 13, 2026, midnight
Non-Invasive Diagnosis of Endometriosis by Questionnaires in Patients Using Contraception.

Background/Objectives: The assessment of endometriosis (EMS)-associated pain is important, but only very few studies address the potential use of questionnaires for non-invasive prediction of the disease. Methods: In a prospective …

Published: Dec. 20, 2025, midnight
Personalized Estimation of Fatigue in Endometriosis Using Wrist-Worn Actigraphy Data and Hierarchical Bayesian Modeling.

Endometriosis is a common chronic condition associated with debilitating pain and fatigue. Wearable technology has the potential to improve symptom monitoring in endometriosis where symptom severity has been traditionally evaluated …

Published: Dec. 5, 2025, midnight
Endometriosis in Carriers of a Pathogenic Variant in BRCA1 or BRCA2: A Descriptive Analysis of a Large Multicentral BRCA Carrier Cohort.

Background: Endometriosis affects an estimated 10% of reproductive-aged women and is associated with increased ovarian cancer risk. While BRCA1/2 mutations are established risk factors for ovarian cancer, their association with …

Published: Dec. 1, 2025, midnight
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