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SPP1 as a key modulator of M2 macrophage polarization promotes endometriosis progression via activation of the FAK/PI3K/AKT pathway: A bioinformatics and experimental study.

Endometriosis (EMs) is a gynecological disorder characterized by chronic inflammation and an aberrant immune microenvironment. In this study, we integrated the GSE6364 dataset from the GEO database to identify differentially …

Published: Sept. 17, 2025, midnight
Combination of circular RNA-miRNA-mRNA expression profiles and bioinformatic analysis in ovarian endometriosis.

Endometriosis is a mysterious disease that affects 5 %-10 % of the women of reproductive age. Circular RNAs (circRNAs), a type of noncoding RNA, are involved in its progression, yet …

Published: Sept. 15, 2025, midnight
Using systems biology and drug repositioning approaches to discover FDA-approved drugs candidates for endometriosis treatment.

Endometriosis is characterized by the presence of endometrial tissue outside the uterine cavity. The administration of drugs designated for this condition has significant adverse effects, such as signs of estrogen …

Published: Sept. 12, 2025, midnight
Differential life cycle toxic effects and molecular mechanisms of Di(2-ethylhexyl) phthalate (DEHP) exposure on the female reproductive system.

Di(2-ethylhexyl) phthalate (DEHP), the most prevalent plasticizer worldwide, can enter the human body via various exposure pathways, including ingestion, inhalation, skin contact, and medical applications. It has been observed to …

Published: Aug. 31, 2025, midnight
First Presentation of Endometriosis: A Case of Acute Large Bowel Obstruction.

The first presentation of endometriosis as acute large bowel obstruction is rare. We present the case of a woman in her 40s with no significant past medical history presenting with …

Published: Aug. 30, 2025, midnight
Bioinformatics-Based Identification of Differentially Expressed Genes in Endometrial Carcinoma: Implications for Early Diagnosis and Prognostic Stratification - Frontiers

Bioinformatics-Based Identification of Differentially Expressed Genes in Endometrial Carcinoma: Implications for Early Diagnosis and Prognostic Stratification Frontiers

Published: Aug. 29, 2025, 6:56 p.m.
Endometriosis Presenting as a Malignant Appearing Cecal Mass.

Endometriosis is a gynecological condition that can manifest in pelvic and extra-pelvic sites, including the gastrointestinal tract. Cecal and appendiceal involvement is rare and can present as anemia, mimicking malignancy. …

Published: Aug. 28, 2025, midnight
Intestinal Endometriosis, A Challenge for Gastroenterologists: A Narrative Review.

Endometriosis is a medical condition where endometrial tissue and glands are found outside the uterine cavity: on ovaries, pelvic peritoneum, rectovaginal septum, bladder, bowel and more. The ectopic tissue is …

Published: Aug. 22, 2025, midnight
Anatomic subtype-specific causal effects of endometriosis on ovarian cancer: a two-sample Mendelian randomization study.

While epidemiological studies have associated endometriosis with ovarian cancer risk, the causal relationships across anatomic subtypes and histotypes remain undefined. Using two-sample Mendelian randomization with 84 genetic instruments (F-statistic = …

Published: Aug. 13, 2025, midnight
Cervical endometriosis mimicking cervical adenocarcinoma: A case report.

Cervical endometriosis is a rare benign condition characterized by ectopic endometrial glands and stroma within the cervix. Its clinical and imaging features resemble those of cervical adenocarcinoma, making preoperative diagnosis …

Published: Aug. 7, 2025, midnight
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