Endometriosis is a chronic, heterogenous disorder in which cyclical hemorrhage and repetitive repair generate ectopic implants that persist, recur, and drive pain and infertility; conventional frameworks emphasizing hormonal aberration and …
Endometriosis is a chronic, estrogen-dependent inflammatory disease characterized by highly individualized, multisystemic symptoms, affecting approximately 10% of females. In this work, we present a long-term prospective study in which 34 …
Rheumatic heart disease (RHD) remains the leading cause of acquired valvular heart disease in low- and middle-income countries, affecting an estimated 40 million individuals and disproportionately affecting children and young …
The causal role of established risk factors for premenstrual disorders (PMDs) remains unclear. We used Mendelian randomization (MR) to assess causality for eight known-risk factors identified through a literature review. …
We aim to elucidate the impact of endometriomas on oocyte developmental competence and identify genetic alterations that may influence ICSI success rates in women of different ages.
Dysmenorrhea is the most common gynaecological condition in women of reproductive age. Approximately 90% of cases are primary dysmenorrhea (PDM) which is not associated with underlying pathology. Dysmenorrhea can have …
Circadian rhythm (CR) is a 24-hour biological cycle regulated by endogenous and environmental factors. Altered CR gene expression has been associated with gestational diabetes mellitus (GDM), potentially affecting vascular regulation …
Endometriosis is a multifactorial, chronic inflammatory disorder that affects a substantial proportion of women during their reproductive years and is frequently associated with pelvic pain and infertility. Accumulating evidence suggests …
The first trimester (FT) of pregnancy is characterized by rapid placental growth and differentiation, rendering this period sensitive to maternal metabolic influences. Maternal obesity is associated with chronic low-grade inflammation …
Data on long-term outcomes of surgical management of rectal endometriosis are scarce and generally provided by cohort studies where choice of surgical technique is based on various uncontrolled factors with …