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Preserved large elastic arterial stiffness and impaired conduit artery endothelial function in patients with endometriosis receiving progestin therapy: A cross-sectional observational study.

To evaluate central arterial stiffness, endothelial function, and circulating vascular biomarkers in women with ovarian endometriosis and to explore their associations compared with age-matched controls.

Bowel endometriosis: from pathogenesis to clinical management.

Bowel involvement is a severe manifestation of deep endometriosis that affects approximately 8-12% of women with endometriosis. Bowel endometriosis is most commonly localised in the rectosigmoid colon and frequently coexists …

Estetrol potentiates progesterone-driven growth restraint while blunting pro-angiogenic activation in murine endometriosis lesions.

Endometriosis is sustained by ectopic endometrial implants that remain proliferative and vascularized, making endocrine modulation a cornerstone of therapy. Estetrol (E4) an endogenous estrogen produced during pregnancy, with selective tissue …

Guided immunotherapy for residual solid tumor: integrating platelets and CAR T cells to reduce post-surgical recurrence.

Postoperative recurrence remains a major obstacle to durable remission in patients with solid tumors, even after complete macroscopic resection. Growing evidence suggests that surgery creates a transient yet highly permissive …

Cryoablation of Abdominal Wall Endometriosis: Evidence Base Calling for Greater Awareness of this Minimally Invasive Option.

Associations Among Parental Rearing Patterns, Psychological Resilience and Coping Styles in Adolescent Females with Endometriosis.

Adolescent endometriosis (EMs) imposes substantial physical and psychological burdens on young female patients, and adaptive coping strategies are vital for their health management. This study aimed to explore the latent …

Low-FODMAP Diet for Gastrointestinal Symptoms in Endometriosis: A Systematic Review.

Background/Objectives: Gastrointestinal (GI) symptoms, including abdominal pain, bloating, altered stool pattern, dyschezia, and nausea, are frequent in women with endometriosis and may persist despite conventional gynecological treatment. The low fermentable …

Suggestive associations between genetically predicted gut microbiota and endometriosis: a two-sample Mendelian randomization study.

Introduction. Endometriosis affects 10-20% of reproductive-age women. Emerging evidence links the gut microbiota to endometriosis pathogenesis, but observational studies are limited by confounding, reverse causation and uncertainty about whether reported …

Modulating IL-11-dependent matrix stiffness to delay ovarian aging.

Recent studies have highlighted the crucial role of mechanical properties in the ovarian microenvironment for ovarian function. However, the mechanisms that cause ovarian matrix stiffening during aging remain incompletely understood. …

Early-life exposures and risk of multiple gynecological diseases: evidence from a large community-based study of 272,706 women.

Early-life exposures may influence long-term reproductive health, but comprehensive population-based evidence remains limited. This study aimed to evaluate the associations between six early-life factors (long-term/recurrent antibiotic use [LRAU], birth weight, …