Latest Articles

Effects of hormonal treatment on the expression of collagen type I, matrix metalloproteinase-1, and tissue inhibitor of metalloproteinases-1 in endometriosis.

Endometriosis is an estrogen-dependent disease, and hormonal treatment is the most common treatment. Both deep infiltrating endometriosis (DIE) and ovarian endometrioma (OV) are characterized by dense surrounding fibrotic tissue. However, …

HMGB-1 Increases Proinflammatory Reaction via TLR4 in Human Granulosa Cells of Endometriosis.

Background/Objectives: Oxidative stress is a critical factor in the development and progression of endometriosis. Granulosa cells, which reside near oocytes in follicles, exhibit steroidogenic activity, and, consequently, influence oocyte quality. …

Shared Genetic Architecture Between Endometriosis and Psychiatric Conditions May Explain Comorbidity.

Endometriosis is a common chronic gynecological disorder with complex and poorly understood etiology and no definitive cure. Beyond pain and infertility, affected individuals frequently experience psychiatric comorbidities, often attributed to …

First birth rates after surgically verified subtypes of endometriosis-a national register study of 9,590 women from Finland.

To study first birth rates according to endometriosis subtype after surgical diagnosis among nulliparous women.

Fragility index analysis for robustness of evidence in randomized controlled trials leading to the US Food and Drug Administration approval of pharmacological therapies for endometriosis.

Targeting Steroid Receptor Coactivators for the Treatment of Benign Female Reproductive Disorders.

Steroid receptor coactivators (SRCs) are master regulators of nuclear receptor signaling and play essential roles in female reproductive physiology. By integrating steroid hormone signaling with growth factors and metabolic pathways, …

Identification and Characterization of m6A Regulators METTL3 and YTHDF2: Unveiling Their Biological Functions in Endometriosis.

Endometriosis (EMs) is a benign gynecological disorder that exhibits several malignant characteristics, including proliferation and angiogenesis. N6-methyladenosine (m6A) modification plays a crucial role in regulating RNA splicing, subcellular localization, translation …

Improving Diagnostic Yield in Peritoneal Endometriosis: Value of Additional Level Sections and Sampling Protocols.

To evaluate whether deeper histologic sections and tissue-blocking practices improve the diagnosis of endometriosis in peritoneal biopsies. We retrospectively reviewed 148 peritoneal biopsy cases with clinical suspicion of endometriosis from …

Primary Invasive Squamous Cell Carcinoma of the Vagina Presenting Three Decades After Total Hysterectomy for Benign Endometriosis: A Case Report.

A 57-year-old woman (G2P2) with a history of total hysterectomy for endometriosis 30 years earlier, presented for a routine gynecological examination without complaints. Speculum examination revealed an erythematous, raised plaque …

Exploring the Early Endometrial-Blastocyst Interactome in Endometriosis: An Integrative Study.

Background: Background: Endometriosis affects 10% of women of reproductive age. Despite the well-known association between endometriosis and infertility, the mechanisms underlying this association remain to be elucidated. Methods: Implantation and …