Endometriosis is a chronic, estrogen-dependent inflammatory disorder affecting ~10% of reproductive-age women. It is underdiagnosed, with delays of 5-12 years. Symptoms include dysmenorrhea, chronic pelvic pain, dyspareunia, dyschezia, dysuria, fatigue, …
Endometriosis is a chronic hormone-responsive disorder linked to infertility, usually characterized by the presence of ectopic endometrium in the pelvis that disrupts local homeostasis. Advances in single-cell "omic" methods have …
Endometriosis affects 11% of women of reproductive age. Diagnosis is often delayed by 6-8 years due to nonspecific symptoms and lack of early detection tools. This study aimed to develop …
Endometriosis is a common gynecological disease associated with pelvic pain and infertility. Despite several existing theories, the etiology and molecular mechanisms of endometriosis remain to be investigated. Here we report …
S. Paul, P. Bhattacharya, P. D. Mahapatra, and S. Swarnakar, "Melatonin Protects Against Endometriosis via Regulation of Matrix Metalloproteinase-3 and an Apoptotic Pathway," Journal of Pineal Research 49, no. 2 …
Oxidative stress has emerged as a key factor regulating female fertility, reproductive aging, and the development of various gynecologic and pregnancy-associated diseases. While physiological concentrations of reactive oxygen species play …
Three-dimensional (3D) organoid and co-culture models have emerged as transformative tools for studying human endometrial function, implantation, and placental development, overcoming key limitations of animal and two-dimensional in vitro systems. …
Progesterone plays a pivotal role in implantation and ongoing pregnancy. In the context of assisted reproductive technology (ART), and in particular frozen embryo transfer (FET), increasing evidence suggests that serum …
Digital symptom checkers (SCs) are increasingly used to support early symptom recognition and care-seeking, yet evidence on their cost-effectiveness remains limited. We conducted an economic evaluation of a digital SC …
A new humoral factor has been detected, within a project aiming to disclose the body's reproductive hormonal brake against tissue overgrowth, micrin ('my-crin'). Factor purification involved fractionation of ovine and …