Microecological modulators-new perspectives for treating sex hormone disorders.
Sex hormone related disorders, characterized by complex etiology and long-term health risks, pose a significant challenge to global health. Hormone-based therapies are often accompanied by adverse effects and fail to …
The enzymatic mechanisms of lactylation and its role in gynecological diseases: a comprehensive review.
Lysine lactylation (Kla) is a novel form of post-translational modification. It utilizes lactate as its core substrate. Through an enzymatic regulatory network, it mediates modifications of both histones and non-histone …
Multi-ancestry genome-wide association and integrated multi-omics analyses of endometriosis and its clinical manifestations.
Endometriosis is a chronic systemic disease affecting ~10% of women, yet its genetic basis and molecular mechanisms remain poorly understood. Hence, here we conducted a genome-wide association study of endometriosis …