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SPP1 as a key modulator of M2 macrophage polarization promotes endometriosis progression via activation of the FAK/PI3K/AKT pathway: A bioinformatics and experimental study.

Endometriosis (EMs) is a gynecological disorder characterized by chronic inflammation and an aberrant immune microenvironment. In this study, we integrated the GSE6364 dataset from the GEO database to identify differentially …

Published: Sept. 17, 2025, midnight
Combination of circular RNA-miRNA-mRNA expression profiles and bioinformatic analysis in ovarian endometriosis.

Endometriosis is a mysterious disease that affects 5 %-10 % of the women of reproductive age. Circular RNAs (circRNAs), a type of noncoding RNA, are involved in its progression, yet …

Published: Sept. 15, 2025, midnight
Integrated GNPS, semi-preparative HPLC, and network pharmacology reveal active ingredients and potential machenisms of Paeonia suffruticosa Andr. leaves in treating endometriosis with anxiety/depression.

Endometriosis (EMs) with anxiety/depression is a common comorbidity of EMs, yet effective treatments are still lacking. Leaves of Paeonia suffruticosa Andr. (PSL) have potential therapeutic effects on EMs and their …

Published: Sept. 15, 2025, midnight
Using systems biology and drug repositioning approaches to discover FDA-approved drugs candidates for endometriosis treatment.

Endometriosis is characterized by the presence of endometrial tissue outside the uterine cavity. The administration of drugs designated for this condition has significant adverse effects, such as signs of estrogen …

Published: Sept. 12, 2025, midnight
Erastin-induced multi-pathway cell death in endometriosis: a mechanistic and translational narrative review.

This narrative review examines the therapeutic potential of Erastin and its derivatives for endometriosis (EMS) by integrating mechanistic, preclinical, and translational perspectives. We conducted a focused review of literature from …

Published: Sept. 10, 2025, midnight
Diagnostic accuracy of combination of CA125 for endometriosis: A network meta-analysis.

Currently, CA125 combined with other biomarkers significantly outperforms CA125 alone in diagnosing endometriosis (EM), but the efficiency of combined diagnosis remains unclear. This network meta-analysis compared the accuracy of CA125 …

Published: Sept. 9, 2025, midnight
Developing the FIGO-IPPS "R U MOVVING SOMe" classification system for female chronic pelvic pain.

The goal was to develop a pragmatic classification system for conditions associated with chronic pelvic pain (CPP), aiming to enhance diagnosis, management, education, and research of CPP. An international, multidisciplinary …

Published: Sept. 8, 2025, midnight
Clinical efficacy and safety of Chinese patent medicines combined with hormonal therapy for endometriosis after laparoscopic surgery: A Bayesian network meta-analysis.

Chinese patent medicines (CPMs), standardized herbal formulations widely used in clinical practice, combined with hormones have shown favorable therapeutic effects in the adjuvant treatment of endometriosis (EMS) after laparoscopic surgery. …

Published: Sept. 6, 2025, midnight
Mechanisms Driving Resistance to Oxidative Stress During Endometrial Stromal Cell Decidualization†.

Decidualization is the transformation of endometrial stromal cells into functionally specialized cells during the early stages of pregnancy. Occurring in mammals that develop invasive hemochorial placentae, decidualization is a pivotal …

Published: Sept. 2, 2025, midnight
Triptorelin associated adverse events evaluated using FAERS pharmacovigilance data.

Triptorelin, a gonadotropin-releasing hormone(GnRH) agonist, is approved by the US Food and Drug Administration(FDA) for treating advanced prostate cancer, endometriosis, and central precocious puberty(CPP) in children aged ≥ 2 years. …

Published: Sept. 1, 2025, midnight
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