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The Gut-Endometriosis Axis: Genetic Mechanisms and Public Health Implications.

Background/Objectives: Endometriosis is a chronic, estrogen-driven gynecological disorder affecting approximately 10% of reproductive-aged women worldwide, with significant physical, psychosocial, and socioeconomic impacts. Recent research suggests a possible involvement of the …

Published: July 30, 2025, midnight
Clinical significance of the CXCL6-CXCR1/CXCR2 chemokine signaling pathway in the peritoneal fluid of patients with endometriosis.

Endometriosis is the presence of endometrial tissue outside the uterine cavity with an accompanying chronic inflammatory process. The etiology of the disease is still not fully understood. An important role …

Published: July 29, 2025, midnight
Optimizing endometriosis diagnosis and mapping: The important role of advanced transvaginal ultrasound.

Endometriosis is estimated to affect 5%-10% of women of reproductive age, making timely diagnosis essential for initiating treatment, alleviating symptoms, and reducing the risk of disease progression. Unfortunately, the diagnostic …

Published: July 29, 2025, midnight
Menopause as a Critical Turning Point in Lipedema: The Estrogen Receptor Imbalance, Intracrine Estrogen, and Adipose Tissue Dysfunction Model.

Lipedema is a chronic, estrogen-sensitive adipose tissue disorder characterized by disproportionate subcutaneous fat accumulation, fibrosis, inflammation, and resistance to fat mobilization. Despite its high prevalence, lipedema remains poorly understood and …

Published: July 23, 2025, midnight
NXF1 suppresses progression of endometrial cancer by interacting with the SRSF3 to regulate SP4 splicing.

Conventional treatments for advanced endometriosis often have limited efficacy due to chemotherapy resistance, recurrence, and metastasis. This study analyzed clinical specimens to investigate the role of NXF1 in endometrial cancer …

Published: July 22, 2025, midnight
Hepatoma-derived growth factor and non-coding RNA network in ovarian cancer patients.

Ovarian cancer (OC) remains the most lethal gynecologic malignancy due to late diagnosis and limited effective biomarkers. Hepatoma-derived growth factor (HDGF) has emerged as an oncogene implicated in tumor progression, …

Published: July 18, 2025, midnight
Exploring the Immune System's Role in Endometriosis: Insights Into Pathogenesis, Pain, and Treatment.

Endometriosis is a common gynecological condition that usually affects women during their reproductive years. The main goal of this narrative review is to understand the role of the innate and …

Published: July 1, 2025, midnight
Changes in the M1/M2 ratio due to andrographolide therapy for deep endometriosis: An experimental study using a BALB/C endometriosis model.

Andrographolide is a compound that serves as an anti-inflammatory agent. M2 macrophages promote the disease, while M1 macrophages inhibit endometriosis progression.

Published: June 30, 2025, midnight
Current Insights into Endometriosis: Hormonal Management, Clinical Outcomes, and Opportunities for Progress.

Endometriosis, a prevalent women's health condition, is associated with persistent pelvic pain and infertility. Despite ongoing research, its precise disease mechanism remains elusive, impeding the discovery of a definitive cure. …

Published: April 8, 2025, midnight
Adoptive transfer of regulatory T cells inhibits the progression of endometriosis-like lesions in regulatory T-cell-depleted mice.

Does the restoration of regulatory T cells (Tregs) suppress the progression of endometriosis?

Published: April 3, 2025, midnight
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