We aimed to generate immortalized stromal cell lines from the ovarian and fallopian tube tissues of a single patient using Sendai virus (SeV) vectors and identify candidate stromal genes involved …
Advanced endometriosis (stage III-IV, per the revised American Society for Reproductive Medicine (rARSM) classification of endometriosis) is associated with a range of pregnancy-related complications. Despite growing evidence, awareness of these …
Pregnancy involves a fine-tuned hormonal interplay between the fetus, placenta, and mother, which shapes long-term developmental outcomes. Endometriosis has been hypothesized to originate in utero due to altered fetal exposure …
The reduction in oocyte competence and ovarian reserve coincides with reproductive ageing; nevertheless, the molecular mechanisms underlying this phenomenon remain poorly understood. Our testable mechanistic hypothesis is that the oxidative …
Objective: The primary goal of treatment for endometriosis (EMS), where pelvic pain is the most significant symptom, is the symptom alleviation. Medical treatment is typically employed until menopause or until …
Acute hemoperitoneum represents a gynecological and surgical emergency with significant morbidity if diagnosis and intervention are delayed. In women of reproductive age, the etiology is most frequently ruptured ectopic pregnancy; …
Adolescent-onset endometriosis is increasingly recognized as a distinct clinical challenge. It often requires years to achieve a diagnosis, leading to prolonged physical and psychological distress and significantly impairing quality of …
This mendelian randomization (MR) study aimed to investigate whether endometriosis, overall and stratified by stage (I/II vs III/IV), confers causal effects on adverse pregnancy and perinatal outcomes.
To study the associations of B cell lymphoma 6 (BCL6) in endometrial endometriosis, and to determine a practice's experience testing BCL6 in patients with recurrent pregnancy loss/recurrent implantation failure (RPL/RIF).
In vitro fertilization (IVF) has revolutionized assisted reproductive technologies (ART), profoundly transforming infertility treatment since its inception. This procedure involves fertilizing an egg with sperm in a controlled laboratory environment, …