We conducted a multi-ancestry genome-wide association study of endometriosis and adenomyosis in almost 1.4 million women, including 105,869 cases, aiming to expand endometriosis loci discovery across ancestries, dissect symptom-specific effects, …
Background: Endometriosis is a chronic disease defined by the presence of endometrial-like tissue outside the uterine cavity. While typically confined to the pelvis, extrapelvic manifestations-including thoracic endometriosis-can occur. Although rare, …
Endocrine dysfunctions refer to alterations in hormone production, release, or regulation that can significantly impact health. In pregnant women or those planning pregnancy, these conditions may manifest as disorders such …
Decidualization is the transformation of endometrial stromal cells into functionally specialized cells during the early stages of pregnancy. Occurring in mammals that develop invasive hemochorial placentae, decidualization is a pivotal …
Endometriosis affects approximately 10 percent of women of reproductive age. Although physical activity has shown beneficial effects for managing endometriosis-related symptoms, women with this condition often engage in lower levels …
Chronic pain is a defining feature of endometriosis and contributes significantly to the diminished quality of life observed in affected individuals. Despite advances in understanding disease pathology, current therapeutic strategies …
Introduction: Shaofu Zhuyu Decoction (SZD) is a traditional Chinese herbal formula commonly used for gynecological disorders involving "blood stasis" and lower abdominal pain. Although applied clinically for endometriosis, evidence regarding …
The gender knowledge gap in medicine, particularly regarding menstruation and disorders such as endometriosis, often results in delayed diagnoses and inadequate care. Many menstruating individuals report dismissal of debilitating symptoms, …
High-throughput sequencing enables efficient processing of DNA and RNA samples in batches, but batch effects can obscure true biological signal. We propose using anticlustering as an automated method to assign …
Current interventions for endometriosis mainly involve hormone therapies but have limited efficacy and unacceptable side effects due to the lack of selectivity to distinguish between endometriosis and endometrial tissues. Elucidating …