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NAC1 Regulates PCK2 Expression and Activates Truncated Gluconeogenesis for Growth Advantage in Ovarian Cancer Cells.

Nucleus accumbens-associated protein 1 (NAC1), a cancer-related transcriptional regulator, is overexpressed in several malignancies, including ovarian cancer. However, its role in ovarian carcinogenesis remains unclear. We aimed to investigate whether …

Published: Sept. 25, 2025, midnight
Estradiol regulates MBOAT1-mediated ferroptosis and participates in the progression of endometriosis.

Endometriosis is an estrogen-dependent disease with unclear pathogenesis. Recent evidence suggests that ferroptosis plays an important role in the development of endometriosis. In this study, we aimed to explore whether …

Published: Sept. 24, 2025, midnight
68Ga-FAPI-04 PET/CT Demonstrates Subtype-specific Uptake Patterns in Endometriosis With Added Diagnostic Value Beyond MRI.

A 44-year-old woman with biopsy-proven endometriosis underwent 68Ga-FAPI-04 PET/CT. MRI revealed bilateral ovarian endometriomas, uterine adenomyosis, and deep pelvic endometriotic lesions. FAPI PET/CT demonstrated concordant uptake in deep infiltrating lesions …

Published: Sept. 24, 2025, midnight
Transvaginal Natural orifice transluminal endoscopic hysterectomy vs. abdominal laparoscopic approach in real-life practices: a retrospective cohort study.

This study aims to retrospectively evaluate the surgical outcomes of total hysterectomy performed via Vaginal Natural Orifice Transluminal Endoscopic Surgery (vNOTES) compared to laparoscopic hysterectomy (LAP) in treating benign gynecologic …

Published: Sept. 24, 2025, midnight
Mendelian Randomization Analysis of the Relationship Between Immune-Related Diseases and Alzheimer's Disease.

Emerging evidence suggests a genetic link between immune-related diseases and Alzheimer's disease (AD), though the underlying mechanisms remain unclear. This Mendelian randomization (MR) study investigates the genetic relationship between six …

Published: Sept. 24, 2025, midnight
Micronutrients in Obstetrics and Gynecology: Mini-Review Article.

Micronutrients are fundamental in maintaining the general health of a woman and play a pivotal role in reproductive health, with heightened importance during pregnancy and lactation. Deficiencies in vitamins and …

Published: Sept. 24, 2025, midnight
Casein Kinase 1α Agonist Pyrvinium Promotes Autophagy to Suppress Endometriosis in Mice.

Endometriosis is a prevalent gynecological disorder characterized by the ectopic presence of endometrial tissue and chronic inflammation. This study aimed to explore the therapeutic potential of the Casein kinase 1 …

Published: Sept. 23, 2025, midnight
Pioneering robotic surgery for complex gynecologic conditions: implementation beyond cancer care.

Minimally invasive surgery was introduced to minimize some of the issues associated with open surgery. Its benefits include fewer complications, less pain and blood loss, shorter hospital stays, quicker recovery, …

Published: Sept. 23, 2025, midnight
Di-(2-ethylhexyl) phthalate induces endometriosis by modulating IGF-1 m6A methylation via the intestinal Odoribacter-butyric acid axis in female rats.

Endometriosis, a complex gynecological disorder characterized by aberrant growth of endometrial tissue outside the uterine cavity, poses a significant challenge to women's health. Emerging evidence implicates environmental pollutants, particularly di-(2-ethylhexyl) …

Published: Sept. 23, 2025, midnight
The endocrine aspects of endometriosis.

Endometriosis is a chronic gynecologic disease of reproductive-age women, causing menstrual pain and infertility. Endocrine and inflammatory mechanisms drive its development, with estrogen/progesterone imbalance contributing to extrauterine implantation and persistence …

Published: Sept. 22, 2025, midnight
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