A transcriptomics-based computational drug repurposing pipeline identifies simvastatin and primaquine as therapeutics for endometriosis.
Endometriosis has limited treatment options, prompting the search for data-driven therapeutics. We previously used a transcriptomics-based computational drug repositioning pipeline and identified several drug candidates. Fenoprofen, our top in silico …
Association of GPR30 Genetic Variants with Recurrent Implantation Failure: A Case-Control Study Comparing Fertile Women, ART Success and RIF Patients.
GPR30 (G-protein coupled receptor 30) plays a key role in regulating reproductive processes, particularly through estrogen signaling. Previous studies have linked GPR30 polymorphisms to female reproductive disorders such as infertility, …
Endothelial cell heterogeneity drives angiogenesis in endometriosis: mechanisms and emerging organoid-based models.
Endometriosis (EMs) is characterized by the establishment and persistence of ectopic lesions, a process fundamentally dependent on aberrant angiogenesis. Endothelial cells (ECs) play a central role in this process; however, …
Single-Cell RNA Sequencing Shows Markedly Elevated Immune Cell Proportions in the Endometrium of Women with Endometriosis-A Narrative Review.
Single-cell RNA sequencing is a state-of-the-art approach to decipher the heterogeneity of RNA transcripts in individual cells and identify different cell types in tissues and organs. Its aim is to …