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The oral GnRH antagonists, a new class of drugs in gynecology: from pharmacokinetics to possible clinical applications.

In ovarian steroid-dependent diseases such as uterine fibroids, endometriosis and adenomyosis, oral GnRH antagonists have emerged as new therapeutic alternatives. These oral GnRH antagonists offer key advantages, including oral administration, …

Published: Dec. 12, 2024, midnight
Endometriosis Associated with Periodontal Disease: Two Case Reports.

Endometriosis is a nonmalignant inflammatory condition characterized by the existence of estrogen-dependent endometrial tissue outside the uterus. Endometriosis and periodontal disease influence several processes, and traditionally, the mechanisms of each …

Published: Dec. 12, 2024, midnight
A narrative review about the intricate crosstalk among endometrium, adipose tissue, and neurons in endometriosis. The multifaceted role of leptin.

Endometriosis is a highly prevalent gynecological disease characterized by the presence of endometrium-like tissue outside the uterus, whose etiopathology is far from being elucidated. The most frequent complains of patients …

Published: Dec. 10, 2024, midnight
Evaluating systemic immune-inflammation indices as predictive markers for endometriosis diagnosis: A retrospective observational study.

Endometriosis is a chronic inflammatory disease for which there is currently no accurate screening test to identify or predict the probability of the disease in individuals. This can often lead …

Published: Dec. 9, 2024, midnight
Causal Relationship Between Endometriosis, Female Infertility, and Primary Ovarian Failure Through Bidirectional Mendelian Randomization.

Endometriosis and its associated gynecological diseases such as female infertility and primary ovarian failure (POF), impose a long-term disease burden on women. This study aims to explore the causal relationships …

Published: Dec. 9, 2024, midnight
Assessing the Accuracy of Cardiovascular Disease Prediction Using Female-Specific Risk Factors in Women Aged 45 to 69 Years in the UK Biobank Study.

Cardiovascular disease (CVD) is the leading cause of mortality in women. We aimed to assess whether adding female-specific risk factors to traditional factors could improve CVD risk prediction.

Published: Dec. 6, 2024, midnight
Retinoic acid homeostasis and disease.

Retinoids, particularly all-trans-retinoic acid (ATRA), play crucial roles in various physiological processes, including development, immune response, and reproduction, by regulating gene transcription through nuclear receptors. This review explores the biosynthetic …

Published: Dec. 6, 2024, midnight
Two Cases of Macroglobulinemia with Elevated Serum CA125: Case Reports and Literature Review.

Waldenström macroglobulinemia (WM) is a relatively rare hematological malignancy characterized by serum monoclonal IgM gammopathy and bone marrow infiltration of lymphoma cells (small B lymphocytes, plasmacytoid lymphocytes, or plasma cells). …

Published: Dec. 4, 2024, midnight
Butyrate as a Potential Modulator in Gynecological Disease Progression.

This review investigates the therapeutic potential of butyrate, a short-chain fatty acid (SCFA) produced by gut microbiota, in the prevention and treatment of various gynecological diseases, including polycystic ovary syndrome …

Published: Dec. 4, 2024, midnight
International standard of Traditional Chinese Medicine techniques: clinical guidelines for dysmenorrhea (2022).

Dysmenorrhea is a common gynecological condition that is further divided into two categories, namely primary and secondary dysmenorrhea. Traditional Chinese Medicine (TCM) gives good clinical results for the treatment of …

Published: Dec. 3, 2024, midnight
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