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A Noninvasive Menstrual Blood-Based Diagnostic Platform for Endometriosis Using Digital Droplet Enzyme-Linked Immunosorbent Assay and Single-Cell RNA Sequencing.

Endometriosis is marked by the ectopic growth, spread, and invasion of endometrial tissue beyond the uterus, resulting in recurrent bleeding, pain, reproductive challenges, and the formation of nodules or masses. …

Published: April 1, 2025, midnight
Influence of endometrial nerve fibers and hormones on pain in women with endometriosis.

The mechanisms behind endometriosis-related pain are not yet fully understood. To determine if there is a difference in the density of endometrial nerve fibers between women with endometriosis and healthy …

Published: April 1, 2025, midnight
Add-on effect of curcumin to dienogest in patients with endometriosis: a randomized, double-blind, controlled trial.

Endometriosis is a chronic gynecological disorder characterized by significant pain and reduced quality of life (QOL). Current treatments, such as dienogest, are not fully effective, prompting the investigation of curcumin …

Published: April 1, 2025, midnight
Laparoscopic purse-string suture technique for total intracorporeal rectosigmoid end-to-end anastomosis after segmental bowel resection.

Bowel endometriosis affects 8-12% of women with infiltrating endometriosis, mostly involving the rectum and sigmoid1. Surgery is preferred when medical therapy fails or is contraindicated. Although segmental resection has shown …

Published: March 31, 2025, midnight
PCDD/Fs in human tissues: A review of global biomonitoring data.

This review investigates the concentrations of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) in internal human organs and tissues - excluding blood - with a particular focus on adipose tissue studies conducted …

Published: March 27, 2025, midnight
Immunopathology of Endometriosis, Molecular Approaches.

Endometriosis (EMS) is a common chronic gynecological disorder affecting 5%-10% of reproductive-age women, often causing infertility, dyspareunia, pain, and limitations in physical and sexual activities. This condition is defined by …

Published: March 26, 2025, midnight
Chronic pelvic pain and botulinum toxin.

Botulinum toxin is being explored as a treatment for chronic pelvic pain, a major cause of suffering and disability in both women and men worldwide. For chronic pelvic pain in …

Published: March 26, 2025, midnight
Ramipril ameliorates endometriosis by inducing oxidative stress-mediated apoptosis in the wistar rat.

Endometriosis is illustrated by the presence of ectopic endometrial cells capable of evading apoptosis outside the uterus. Apoptotic and anti-apoptotic factors in the extra uterine microenvironment can be compromised by …

Published: March 24, 2025, midnight
Mechanisms of Endometrioma-Mediated Ovarian Damage: Myths and Facts.

Ovarian endometriomas (OEMs), cystic formations within the ovaries, are a significant manifestation of endometriosis and present in 20-40% of affected women. Despite extensive research, the pathogenesis of endometriosis remains unclear, …

Published: March 21, 2025, midnight
Utilising Human Myometrial and Uterine Fibroid Stem Cell-Derived Three Dimentional Organoids as a Robust Model System for Understanding the Pathophysiology of Uterine Fibroids.

Uterine fibroids (UFs) are the most common benign gynecologic tumours affecting women of reproductive age. This study aims to deepen the understanding of UFs complex aetiology through harnessing the power …

Published: March 20, 2025, midnight
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