Adult stem cells are thought to drive the regenerative potential of the endometrium and contribute to the pathogenesis of endometriosis, however, their identity and defining features remain to be characterized. …
Endometriosis is associated with nociceptive pain, as well as peripheral and central sensitization. Evidence-based treatment suggestions for controlling endometriosis should be based on the convergence of the best scientific evidence, …
The LYSET gene encodes the LYSET transmembrane protein, which regulates lysosome biogenesis by activating the mannose-6-phosphate (M6P) pathway. This is an autosomal recessive, ultrarare, and severe progressive skeletal dysplasia with …
Obesity is a multifactorial chronic disease with pandemic-level prevalence, characterized by excessive or abnormal fat accumulation, dysregulation of body homeostasis, and chronic low-grade inflammation. This complex comorbidity shares some etiological …
Endometriosis is a chronic estrogen-dependent inflammatory disease that impairs fertility and quality of life. Dienogest, the current standard therapy, provides symptom relief but does not correct immune imbalance or prevent …
This study investigated how chronic pelvic pain (CPP) develops using rhesus macaques with naturally occurring endometriosis and a multiple-lesion induction mouse model (MIM), as repeated retrograde menstruation is considered an …
Background/Objectives: Deep endometriosis is a chronic inflammatory disease that significantly affects fertility. The objective was to evaluate the magnitude of the effect of minimally invasive nerve-sparing complete excision of endometriosis …
Endometriosis is a prevalent inflammatory disease affecting approximately one in ten women, characterized by endometrial tissue outside the uterus. Despite its high incidence, treatment options are limited, and the underlying …
Endometriosis and major depressive disorder (MDD) pose significant global health burdens. Despite pathophysiological overlaps, existing epidemiological studies predominantly examine their unidirectional associations, often constrained by cross-sectional designs and small sample …
Endometriosis is a chronic gynecological disorder marked by the growth of endometrial-like tissue outside the uterus, often leading to pelvic pain, inflammation, and infertility. Despite its global prevalence, diagnosis remains …