Prostate-specific membrane antigen immunostaining in endometriosis: preliminary findings and a case of in vivo imaging with gallium-68 positron emission tomography/computed tomography.
Peritoneal Mesonephric-Like Adenocarcinoma Arising in Endometriosis: Case Report and Review of the Literature Expanding the Spectrum of Extrauterine Mesonephric-Like Adenocarcinomas.
BackgroundMesonephric-like adenocarcinoma (MLA) is a rare type of Müllerian carcinoma that poses significant diagnostic challenges, especially at extrauterine sites. Its morphologic and immunophenotypic overlap with other carcinomas can lead to …
Evaluating Subtypes of Endometriosis in Rhesus Macaques (Macaca mulatta) Using Clinical Findings and Immunohistochemistry.
Endometriosis is defined as endometrial tissue outside of the uterus. It is a debilitating, complex, and underdiagnosed condition, impacting approximately 10%-15% of reproductive-aged women worldwide. Endometriosis is associated with chronic …
Exploration of driver biomarkers and immune microenvironment in patients with endometriosis: Evidence from RNA-seq and machine learning.
Endometriosis (EM) is a condition that impacts roughly 10% of women within the reproductive age demographic on a global scale. Due to the limitations of conventional diagnostic techniques for endometriosis, …
Detecting the body's reproductive hormonal brake against tissue overgrowth: Micrin/SgII-70.
A new humoral factor has been detected, within a project aiming to disclose the body's reproductive hormonal brake against tissue overgrowth, micrin ('my-crin'). Factor purification involved fractionation of ovine and …
Establishment of a xenograft model of endometriosis-associated fibrosis using human immortalized endometrial stromal cells overexpressing HOXC8.
Endometriosis is a disease characterized by fibrosis and adhesions. There are still no treatment methods targeting these conditions. One reason for this is the lack of useful animal models to …
Endometriomas are heterogeneous for functional FSH receptor expression and steroidogenic function.
We investigated whether ovarian endometriomas uniformly express functional FSH receptors (FSHR) and respond to FSH by activating transcriptional programs that drive aromatase and steroid hormone production. Endometrioma cyst capsules were …
Uterine Arteriovenous Malformations: An Underrecognized Putative Cause of Postpartum Hemorrhage, Abnormal Uterine Bleeding, and Pelvic Pain.
Arteriovenous malformations (AVMs) are vascular anomalies defined by direct communications between arteries and veins with bypassing of the capillary network. Such lesions may be congenital or acquired. In the uterus, …
Aberrant Progesterone Receptor (PGR) expression is associated with Estrogen Receptor 1 (ESR1) expression in the endometrium from infertile women with endometriosis.
Estrogen receptor 1 (ESR1) and progesterone receptor (PGR) are essential regulators for endometrial receptivity and embryo implantation. Their expression is dysregulated in women with endometriosis-associated infertility. However, the relationship between …