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Identification of the Piperidyl Urea Derivative BAY-439 as a Potent and Selective Inhibitor of Human Phospholipase A2 Group V (hPLA2-G5) for the Treatment of Inflammatory Pain.

Human Phospholipase A2 Group V (hPLA2-G5) is elevated in inflammatory conditions and promotes neutrophil and macrophage recruitment. Its enzymatic activity activates lipid receptors and cytosolic phospholipase A2 (cPLA2), leading to …

Published: May 19, 2026, midnight
ESPriT1: The effectiveness of laparoscopic treatment of isolated superficial peritoneal endometriosis for managing chronic pelvic pain in women: a randomised controlled feasibility trial.

Endometriosis is a chronic pain condition that affects >190 million people worldwide. It is recommended in clinical guidelines to remove the most common type of endometriosis, 'superficial peritoneal endometriosis' (SPE), …

Published: May 19, 2026, midnight
Piezo1 mediates hypoxia-induced endometriosis fibrosis via the mtDNA -dependent cGAS-STING pathway.

Endometriosis (EMs) is a prevalent gynecological disorder characterized by the ectopic growth of functional endometrial tissue, and its fibrotic pathology represents a primary contributor to chronic pain and infertility in …

Published: May 19, 2026, midnight
BBC star left on floor in intense pain as she shares reality of debilitating condition - MSN

BBC star left on floor in intense pain as she shares reality of debilitating condition MSN

Published: May 18, 2026, 11:05 p.m.
Easing pain: Way to slash endometriosis diagnosis by years - NT News

Easing pain: Way to slash endometriosis diagnosis by years NT News

Published: May 18, 2026, 2:19 p.m.
HSD11B1 suppresses ferroptosis in endometrial stromal cells through the JUND/IL-10 axis to promote endometriosis progression.

Endometriosis (EMs) is a common gynecological disorder characterized by ectopic endometrial tissue growth, leading to chronic inflammation and pelvic pain. Despite its high prevalence, the molecular mechanisms underlying EMs remain …

Published: May 18, 2026, midnight
Predicting superficial peritoneal endometriosis in symptomatic women with negative examination and imaging.

To develop a predictive risk score for superficial peritoneal endometriosis (SPE) in patients with negative examination and imaging based on symptoms and quality of life measures DESIGN: Multicenter nested case-control …

Published: May 18, 2026, midnight
Rates of Premature Ovarian Insufficiency and Surgical Menopause in Patients with Endometriosis.

Endometriosis is a chronic disorder that affects approximately 10% of reproductive aged women and can have wide-ranging detrimental effects. While endometriosis is known to be associated with early menopause, the …

Published: May 18, 2026, midnight
Chronic pain sufferers flagged as 'frequent flyers' and denied treatment in EDs - The Canberra Times

Chronic pain sufferers flagged as 'frequent flyers' and denied treatment in EDs The Canberra Times

Published: May 17, 2026, 11:15 p.m.
Bindi Irwin's emotional health update after years of inescapable pain - MSN

Bindi Irwin's emotional health update after years of inescapable pain MSN

Published: May 17, 2026, 10:16 a.m.
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