Endometriosis is a chronic systemic disease affecting ~10% of women, yet its genetic basis and molecular mechanisms remain poorly understood. Hence, here we conducted a genome-wide association study of endometriosis …
Mangroves are valuable reservoirs of diverse phytochemicals with significant therapeutic potential. Beyond their ecological roles, these bioactive compounds can influence epigenetic mechanisms, heritable changes in gene expression without alterations in …
Background: Bowel surgery is a key component of advanced deep endometriosis management, with anastomotic leakage representing the most serious postoperative complication. This study aimed to identify risk factors for dehiscence …
Ovarian cancer was the eighth most frequently diagnosed cancer among women in 2022. The global age-standardized incidence rate of ovarian cancer decreased from 7.22/100,000 to 6.71/100,000 from 1990 to 2021. …
Endometriosis is associated with nociceptive pain, as well as peripheral and central sensitization. Evidence-based treatment suggestions for controlling endometriosis should be based on the convergence of the best scientific evidence, …
Transvaginal ultrasound-guided oocyte retrieval is required for assisted reproductive technology. This is a short and minimally invasive, but painful procedure. There are no clinical guidelines on optimal pain management. We …
To assess whether high-dose folic acid supplementation (4-5 mg/day), initiated before conception, reduces the risk of miscarriage and improves pregnancy rates compared to standard-dose supplementation (0.4 mg/day).
Dyslipidaemia is related to endometriosis, but it is not known which lipid component is most relevant, and whether the observed correlation reflects the causal relationship. The relationship between triglycerides (TG) …
Phthalates (PAEs), typical endocrine-disrupting chemicals (EDCs) that accumulate in the human body to induce reproductive toxicity, have epidemiological links to endometriosis (EM), but the underlying micro-mechanisms remain unclear. Ferroptosis is …
Background: Endometriosis is a chronic, estrogen-dependent inflammatory disorder. It is associated with hormonal dysregulation, pelvic pain, and a reduced quality of life. Dietary factors may influence disease development and symptom …