Identification of a Potential Biomarker PDGFRA for Endometriosis Based on Comprehensive Analysis of Multiple Omics Data.
Endometriosis (EMs) is a common chronic inflammatory gynecological disorder. But the exact pathogenetic mechanism of the disease is not clear, with some theories proposing that the disease is caused by …
TMEM119 Links to Ovarian Endometriosis Progression via MAPK-Mediated Suppression of Ectopic Endometrial Stromal Cell Senescence.
Transmembrane protein TMEM119 has been implicated in tumor progression (e.g., ovarian cancer), but its role and underlying mechanism in ovarian endometriosis (EM) remain elusive. Thus, this study aimed to investigate …
Dietary Caloric Restriction Suppresses Endometriosis by Inhibiting STAT3/ERK Pathways.
Endometriosis is a chronic, estrogen-dependent inflammatory condition that affects approximately 10% of reproductive-age women and is frequently associated with infertility and pelvic pain. Unlike many estrogen-dependent disorders, epidemiologic studies have …
Advances in the Role of Endometrial Microbiota Alterations in the Pathogenesis of Endometriosis.
The uterine cavity was formerly considered sterile; however, over recent years, researchers have identified the presence of endometrial microbiota. An imbalance in the endometrial microbiota, or dysbiosis, has been shown …
Targeting HSP90 as a therapeutic approach for endometriosis: insights from proteomic analysis.
Endometriosis, a chronic inflammatory condition characterized by pain and infertility, remains a clinical challenge. Current hormonal and surgical treatments are often limited by side effects and high recurrence rates. In …
Aberrant Progesterone Receptor (PGR) expression is associated with Estrogen Receptor 1 (ESR1) expression in the endometrium from infertile women with endometriosis.
Estrogen receptor 1 (ESR1) and progesterone receptor (PGR) are essential regulators for endometrial receptivity and embryo implantation. Their expression is dysregulated in women with endometriosis-associated infertility. However, the relationship between …
Drospirenone promotes apoptosis in ectopic but inhibits proliferation in eutopic human endometrial stromal cells.
Endometriosis is a complex gynecological condition characterized by endometrial tissue growing outside the uterus. In many in vitro studies, almost all progestins have indicated the anti-proliferation and apoptosis of endometriotic …
Corrigendum to "Decreased expression of KLF6 in ectopic endometrial stromal cells contributes to endometriosis progression by targeting CTNNB1" [Cellular Signalling 120 (2024) 111230].