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Steroidal alkaloids as multi-target therapeutics for the treatment of endometriosis.

Endometriosis is a chronic inflammatory disease characterised by ectopic endometrial tissue, progressive fibrosis and chronic pain, with a pathogenesis that goes beyond oestrogen dependence. The central question this review seeks …

Published: July 4, 2026, midnight
Effects of lactoferrin and progesterone on the endometriotic lesion in a female rat model.

Lactoferrin (LF), a multifunctional glycoprotein of the transferrin family, exhibits anti-inflammatory and immunomodulatory properties. Endometriosis is an estrogen-dependent chronic inflammatory disease commonly treated with progesterone therapy; however, progesterone receptor (PGR) …

Published: June 30, 2026, midnight
Chemokine CCL21 promotes the pathological progression of endometriosis by regulating inflammatory cytokine expression and activating the NF-κB signaling pathway.

Endometriosis, affecting approximately 10% of reproductive-aged women worldwide, is widely recognized as a chronic inflammatory disease. Inflammation-related genes (IRGs) play a crucial role in the occurrence and progression of various …

Published: June 29, 2026, midnight
The opioid system in endometriosis: implications for endometrial receptivity and reproductive outcomes.

Endometriosis, a chronic inflammatory disease affecting 10-15% of women of reproductive age, remains a leading cause of female subfertility. While current management strategies focus on surgical excision and hormonal suppression, …

Published: June 29, 2026, midnight
Bladder endometriosis: a current overview of pathogenesis, diagnosis, and treatment approaches.

Endometriosis is a chronic inflammatory disease affecting approximately 10% of women of reproductive age. Urinary tract involvement is rare, occurring in approximately 1-2% of cases, with the bladder being the …

Published: June 27, 2026, midnight
A transdiagnostic cognitive model of depression and anxiety in chronic inflammatory disease: Evidence from multiple sclerosis and endometriosis.

Depressive and anxiety symptoms are prevalent in Multiple Sclerosis (MS) and Endometriosis (EMS), yet their underlying processes remain poorly understood. Guided by a transdiagnostic framework (Nolen-Hoeksema & Watkins, 2011), this …

Published: June 14, 2026, midnight
RNF34 restrains endometriosis through SREBP1-dependent metabolic-immune crosstalk.

Endometriosis is a chronic inflammatory disease with cancer-like features, yet the mechanisms linking metabolic dysregulation to immune remodeling during lesion progression remain poorly understood. Here, we identify the ubiquitin E3 …

Published: June 13, 2026, midnight
Molecular Insights Into Endometriosis for Early Detection and Therapeutic Targets.

Endometriosis is a hormone-dependent chronic inflammatory disease associated with pain and infertility, remains diagnostically and therapeutically challenging due to its multifactorial nature. Molecular mechanisms of the dynamic changes during disease …

Published: June 10, 2026, midnight
Identification and diagnostic potential of pyroptosis-related genes in endometriosis: A novel bioinformatics analysis and validation.

Endometriosis (EMs) is a chronic inflammatory disease characterized by ectopic endometrial growth. This study aimed to identify and analyze potential signatures of pyroptosis-related genes in EMs.

Published: June 9, 2026, midnight
PBMC-derived FGF, PDGF, VEGF and GM-CSF secretion in endometriosis: a case-control in vitro study.

Endometriosis is a chronic inflammatory disease with immune dysregulation in which angiogenic, and hematopoietic mediators are thought to contribute to ectopic lesion establishment and persistence. Whether circulating immune cells are …

Published: June 4, 2026, midnight
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