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CX3CR1/P2X4R signaling-mediated spinal microglial M1 polarization contributes to chronic pelvic pain in endometriosis.

Deeply infiltrating endometriosis (DIE), characterized by its extrauterine invasion, is strongly associated with chronic pelvic pain (CPP). Peripheral-central sensitization synergistically contribute to the pathogenesis of CPP in endometriosis.

Published: March 5, 2026, midnight
High prevalence of endometriosis in women with chronic pelvic pain and confirmed pelvic varicosities: a multiparametric MRI study.

Chronic Pelvic Pain (CPP) presents significant diagnostic challenges, often involving multiple pathologies, including endometriosis and pelvic venous disorders. This study examined the prevalence of endometriosis among women with confirmed pelvic …

Published: March 3, 2026, midnight
An Overview of Endometriosis and Potential Pharmacogenetic Targets.

Endometriosis is a chronic inflammatory disease characterized by the presence of endometrial-like tissue outside the uterine cavity. It affects approximately 10-15% of women of reproductive age globally and is characterized …

Published: Feb. 25, 2026, midnight
Pelvic Congestion Syndrome: The Gynecological Perspective.

Background/Objectives: Chronic pelvic pain (CPP) is defined as pelvic pain lasting longer than six months and is a common yet often overlooked condition, affecting over 40% of women worldwide and …

Published: Feb. 22, 2026, midnight
Behavioral attenuation of marble burying and digging mirrors evoked and non-evoked phenotypes in the endometriosis mouse model.

Endometriosis (ENDO) is an estrogen-dependent chronic gynaecological manifestation of uterine fragments attached outside of the uterus, accompanied by debilitating chronic pelvic pain. The evoked assays often employed fail to capture …

Published: Feb. 20, 2026, midnight
Uterine Arteriovenous Malformations: An Underrecognized Putative Cause of Postpartum Hemorrhage, Abnormal Uterine Bleeding, and Pelvic Pain.

Arteriovenous malformations (AVMs) are vascular anomalies defined by direct communications between arteries and veins with bypassing of the capillary network. Such lesions may be congenital or acquired. In the uterus, …

Published: Feb. 20, 2026, midnight
The value of a non-invasive bladder sensitivity paradigm in chronic pelvic pain.

We explore bladder sensitivity profiles in females with chronic pelvic pain, using a non-invasive bladder sensitivity paradigm. We aim to determine how profiles differ between groups defined by symptoms; groups …

Published: Feb. 18, 2026, midnight
A Previous History of Endometriosis Elevates Irritable Bowel Syndrome Risk in Middle-Aged and Older Women: A UK Biobank Cohort Study of 225,703 Participants.

Endometriosis (EMT) and irritable bowel syndrome (IBS) disproportionately affect middle-aged and older women, where overlapping symptoms (e.g., chronic pelvic pain, bloating) and shared inflammatory mechanisms may drive comorbidity. However, large-scale …

Published: Feb. 16, 2026, midnight
Symptom Profiles and Anatomical Distribution of Deep Infiltrating Endometriosis.

Endometriosis is known to affect women worldwide, and most commonly involves chronic pelvic pain and infertility. Deep infiltrating endometriosis (DIE) is a condition that may involve the bladder, ureter, and …

Published: Feb. 16, 2026, midnight
Differences in response to dienogest therapy among different phenotypes of endometriosis: A single-center retrospective cohort analysis.

This study aims to investigate the differences in response to dienogest (DNG) therapy among patients with 3 different phenotypes of endometriosis: ovarian endometrioma (OMA), superficial peritoneal endometriosis (SUP), and deep …

Published: Feb. 15, 2026, midnight
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