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Therapeutic Effects and Mechanisms of Alcohol Extracts from Polygala fallax Hemsl on Endometriosis in Rats.

Endometriosis is a chronic estrogen-dependent inflammatory disease that significantly affects women's health. Polygala fallax Hemsl. (PFH), a traditional Zhuang medicine, has been frequently used for gynecological disorders. This study investigated …

Published: March 14, 2025, midnight
The Molecular and Cellular Mechanisms of Endometriosis: From Basic Pathophysiology to Clinical Implications.

Endometriosis is a complex gynecological disorder characterized by endometrial-like tissue growing outside the uterus, leading to chronic pain, infertility, and reduced quality of life. Its pathophysiology involves genetic, epigenetic, immune, …

Published: March 10, 2025, midnight
Stem cell theory: A new horizon for the treatment of endometriosis by targeting mesenchymal stem cell.

Endometriosis is a prevalent chronic gynecological disease that poses significant challenges for treatment due to its extensive lesions, diverse morphology, unknown etiology, and tendency for recurrence. In the early 21st …

Published: March 7, 2025, midnight
Impact of miR-214-5p and miR-21-5p From Hypoxic Endometrial Exosomes on Human Umbilical Cord Mesenchymal Stem Cell Function | Newswise - Newswise

Impact of miR-214-5p and miR-21-5p From Hypoxic Endometrial Exosomes on Human Umbilical Cord Mesenchymal Stem Cell Function | Newswise Newswise

Published: Feb. 26, 2025, 5 p.m.
Endostatin-expressing endometrial mesenchymal stem cells inhibit angiogenesis in endometriosis through the miRNA-21-5p/TIMP3/PI3K/Akt/mTOR pathway.

Endometriosis is a chronic inflammatory and neoangiogenic disease. Endostatin is one of the most effective inhibitors of angiogenesis. Mesenchymal stem cells (MSCs) have been investigated as compelling options for cell …

Published: Nov. 26, 2024, midnight
Effects of Exosomes from Menstrual Blood-derived Stem Cells and Ginger on Endometriotic Stem Cells.

Menstrual blood-derived stem cells from endometriosis patients (E-MenSCs) have different gene expression patterns than those from healthy nonendometriotic females (NE-MenSCs). Exosomes extracted from mesenchymal stem cells and plants are considered …

Published: Nov. 20, 2024, midnight
Mesenchymal stem cells: Guardians of women's health.

Mesenchymal stem cells (MSCs) have attracted more and more attention because of their multidirectional differentiation potential, immune regulatory abilities and self-renewal capacity. In recent years, their use has become prominent …

Published: Nov. 8, 2024, midnight
Extracellular Hsp70 and Circulating Endometriotic Cells as Novel Biomarkers for Endometriosis.

Stress-inducible heat shock protein 70 (Hsp70), which functions as a molecular chaperone and is frequently overexpressed in different cancer cell types, is present on the cell surface of tumor cells …

Published: Oct. 30, 2024, midnight
Advances in Mesenchymal Stem Cell Research Applications for Female Infertility-Mechanisms, Efficacy Parameters, Challenges and Future Roadmap.

Infertility affects approximately 15-20% of couples globally, with female factors contributing to nearly half of cases. Conditions such as polycystic ovary syndrome, endometriosis, tubal damage and premature ovarian failure are …

Published: Oct. 8, 2024, midnight
Different Effect of Dienogest on Endometrium Mesenchymal Stem Cells Derived from Healthy and Endometriosis Tissues.

Endometriosis (EM) is an inflammatory condition in which the endometrium is observed to develop outside the uterine cavity. Endometrium has conventionally been recognized as a rich source of endometrial mesenchymal …

Published: Sept. 18, 2024, midnight
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