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Endometriosis-associated infertility alters the microRNA signatures of cumulus cells with a particularly pronounced effect in oocytes that failed fertilization.

Endometriosis (E) is multifactorial disease affecting around 10% of women worldwide. The association between E and infertility is clinically well recognized. For E patients to achieve a successful pregnancy, assisted …

Published: Sept. 26, 2025, midnight
Female reproductive toxicity after exposure to malathion or diazinon: a systematic review of rodent and human studies.

Malathion and diazinon are pesticides widely used in agriculture as well as for domestic and veterinary purposes to control pests, such as scale insects, aphids, and fleas. However, these compounds …

Published: Sept. 4, 2025, midnight
Effect of endometriosis and adenomyosis on oocyte quality: an evaluation of 205,978 oocytes.

Does the presence of endometriosis and/or adenomyosis, adversely affect oocyte morphology?

Published: Aug. 29, 2025, midnight
Peritoneal Fluid Modulates Redox Balance and RNA Integrity in Mouse Oocytes: Insights into Endometriosis-Related Oxidative Stress.

Reactive oxygen species (ROS) are vital for oocyte development, yet the redox state of peritoneal fluid may differ between health and disease. This study investigates the effects of peritoneal fluid …

Published: Aug. 20, 2025, midnight
Precision Therapeutic and Preventive Molecular Strategies for Endometriosis-Associated Infertility.

Endometriosis, a chronic estrogen-dependent disorder defined by ectopic endometrial-like tissue growth, causes pelvic pain and infertility in reproductive-age women. Despite its prevalence, the underlying mechanisms driving lesion persistence and reproductive …

Published: Aug. 9, 2025, midnight
The Functional Role of Cumulus Cells and Their Influence on Oocyte Quality: A Systematic Review.

A systematic review was conducted pertaining to the biologic processes of cumulus cells and measures of oocyte quality. The initial search yielded 18,549 articles, and after screening, 65 studies were …

Published: Aug. 6, 2025, midnight
In Vivo Shadows and In Vitro Light: The Early Embryological Journey Amid Endometriosis.

Endometriosis significantly impacts fertility through complex mechanisms. These include chronic inflammation, oxidative stress, and anatomical distortion. These mechanisms impair oocyte quality, embryo development, and implantation. While in vivo challenges persist, …

Published: July 29, 2025, midnight
Interplay of Oxidative Stress, Autophagy, and Rubicon in Ovarian Follicle Dynamics: Orchestrating Ovarian Aging.

Organ functions generally decline with age, but the ovary is a prototypical organ that undergoes functional loss over time. Autophagy plays a crucial role in maintaining organ homeostasis, and age-related …

Published: July 27, 2025, midnight
The Effects of Endometriosis on Oocyte and Embryo Quality.

Endometriosis is a complex and multifaceted gynecological disorder characterized by the abnormal growth and presence of endometrial-like tissue outside the confines of the uterine cavity. It can lead to a …

Published: March 28, 2025, midnight
Update on the pathogenesis of endometriosis-related infertility based on contemporary evidence.

Endometriosis, the most prevalent cause of infertility, is associated with anatomical distortion leading to adhesions and fibrosis, as well as endocrine abnormalities and immune disorders. This review discusses the mechanisms …

Published: March 10, 2025, midnight
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