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Impact of Intraoperative Clonidine on Postoperative Opioid Use in Patients With Endometriosis: A Randomized Controlled Trial.

Patients with endometriosis undergoing surgery are at risk of moderate-to-severe postoperative pain. Clonidine, an alpha-2 agonist with analgesic properties, may improve multimodal pain management in these patients.

Published: Dec. 4, 2025, midnight
Expanding the genetic landscape of endometriosis: Integrative -omics analyses implicate key genes and pathways in a multi-ancestry study of over one million women.

We report the findings of a genome-wide association study (GWAS) meta-analysis of endometriosis across 14 biobanks worldwide, including 32% non-European patient participants, as part of ​the ​Global Biobank Meta-Analys​i​s Initiative​ …

Published: Dec. 4, 2025, midnight
Infertility management in patients with bowel endometriosis: the current landscape and the promise of randomised trials: a narrative review.

The management of infertility in women with bowel endometriosis remains a significant clinical challenge. The two primary therapeutic approaches include first-line medically assisted reproduction (MAR) and primary bowel surgery, with …

Published: Dec. 3, 2025, midnight
AI-Driven Advances in Women's Health Diagnostics: Current Applications and Future Directions.

Background: Women's health has historically served as an incubator for major medical innovations yet often faces relative neglect in sustained funding and implementation. The rise of artificial intelligence (AI) and …

Published: Dec. 3, 2025, midnight
Natural bioactive compounds and herbal medicines targeting common signaling pathways in endometriosis: mechanisms and therapeutic implications.

For a very long time, herbal treatments have served as remedies for various humans and animals. Natural compounds typically have multiple pharmacological actions because they interact with various biological targets. …

Published: Dec. 2, 2025, midnight
The role of pharmacotherapy in the treatment of endometriosis: an update.

Endometriosis is a chronic inflammatory condition affecting ~10% of reproductive-age individuals and contributing significantly to infertility, pain, and reduced quality of life. Since our 2020 review, new pharmacologic strategies, updated …

Published: Dec. 2, 2025, midnight
Transcriptional coregulator ZMIZ1 modulates estrogen responses that are essential for healthy endometrial function.

Estrogen is a critical regulator of endometrial health. Aberrant estrogen stimulation can result in infertility, endometrial cancer, and endometriosis. Here, we identified Zinc Finger MIZ-Type Containing 1 (Zmiz1) as a …

Published: Dec. 1, 2025, midnight
Is endometriosis staging related to the type and intensity of patients' complaints? A systematic review and meta-analysis.

To evaluate the association between the endometriosis staging and the type and intensity of pain reported by patients, describing the pain intensity across different pain types.

Published: Dec. 1, 2025, midnight
Deep endometriosis: evaluation of ENZIAN and #ENZIAN classification systems by MRI compared with surgery-a meta-analysis.

To assess the reproducibility and the diagnostic accuracy of MRI for the assessment of (#)ENZIAN classification in patients with deep endometriosis by means of a meta-analysis.

Published: Nov. 29, 2025, midnight
Regarding "A Multicenter Study Assessing the Diagnostic Accuracy of Ultrasonographic Features of the Uterosacral Ligaments in Patients with and without Endometriosis".

Published: Nov. 29, 2025, midnight
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