Regulatory T-cells (Tregs) are central to peripheral immune tolerance and act as key players that sustain the immune homeostasis required for embryo receptivity, implantation, and placentation. Treg dysfunction accelerates inflammation, …
Abnormal expression levels of microRNAs are associated with numerous diseases in the female reproductive tract. A small subset of human endogenous retroviruses (HERVs) genes have retained open reading frames (ORFs) …
Pregnancy involves a fine-tuned hormonal interplay between the fetus, placenta, and mother, which shapes long-term developmental outcomes. Endometriosis has been hypothesized to originate in utero due to altered fetal exposure …
Adolescent-onset endometriosis is increasingly recognized as a distinct clinical challenge. It often requires years to achieve a diagnosis, leading to prolonged physical and psychological distress and significantly impairing quality of …
Normal uterine function depends on cyclical regeneration and the capacity to sustain pregnancy. A cesarean incision represents an injury to this remarkable organ. Although the uterus possesses exceptional healing potential, …
Cesarean delivery is a common procedure, currently accounting for one-third of live births in the US. In the acute post-operative setting, it can be difficult to distinguish changes of the …
Per- and polyfluoroalkyl substances (PFAS) are reportedly associated with adverse obstetric outcomes, including premature labor and gestational diabetes. We aimed to evaluate associations of maternal PFAS exposure with obstetric and …
Steroid receptor coactivators (SRCs) are master regulators of nuclear receptor signaling and play essential roles in female reproductive physiology. By integrating steroid hormone signaling with growth factors and metabolic pathways, …
Uterine rupture is an infrequent yet sometimes fatal complication of a subsequent vaginal birth attempt following a previous uterine surgery. We have chosen to write about spontaneous uterine ruptures following …
Damage control surgery (DCS) is a staged surgical strategy for rapid control of life-threatening bleeding, followed by physiological stabilization and delayed definitive repair. Abdomino-pelvic packing (APP)-placing compressive material within the …