Endocrine disrupting chemicals (EDCs) have been associated with disorders affecting female reproductive health, although the precise causal connections and underlying pathways between these substances and such disorders remain incompletely elucidated. …
We report the findings of a genome-wide association study (GWAS) meta-analysis of endometriosis across 14 biobanks worldwide, including 32% non-European patient participants, as part of the Global Biobank Meta-Analysis Initiative …
Endometriosis is a chronic inflammatory estrogen-dependent inflammatory disorder. Theobromine has been implicated in diverse health benefits, including anti-inflammatory and vasodilatory properties. However, the precise association between theobromine and endometriosis remains …
Endometriosis (EMs) and depression are both common conditions that have a significant negative impact on quality of life. However, it is still unclear about the relationship between them. The study …
Evidence have indicated a correlation between sleep disorders and endometriosis, but the causal relationship remains uncertain. This study utilized Mendelian randomization (MR) approach to investigate the causal associations between sleep …
Endometriosis is a common gynecologic condition that causes chronic, life-altering symptoms including pain and infertility. There is an urgent need for new non-hormonal targeted therapeutics to treat endometriosis, but until …
This study aims to assess whether endometriosis causally increases the risk of IBD through Mendelian randomisation (MR) analysis and to elucidate potential mechanisms using in vitro experiments. A two-sample Mendelian …
While epidemiological studies have associated endometriosis with ovarian cancer risk, the causal relationships across anatomic subtypes and histotypes remain undefined. Using two-sample Mendelian randomization with 84 genetic instruments (F-statistic = …
Endometriosis has been linked to several systemic complications, including cardiovascular disease (CVD), atrial fibrillation (AF), heart failure (HF), hypertension, stroke, and ischemic stroke. The potential causal relationship between endometriosis and …
Dietary factors have recently been recognized as potentially influential in the pathogenesis of endometriosis (EM), yet studies on the causal relationship between dietary preferences and EM are limited. The present …