Latest Articles

Eutopic echoes ectopic: organoid-based evidence of shared hormone dysregulation in endometriosis.

A Customizable Tyramide Signal Amplification-Based Multiplex Immunofluorescence Protocol for FFPE Tissues.

Formalin-fixed paraffin-embedded (FFPE) tissues represent an invaluable resource for both basic and clinical research due to their stable preservation of tissue architecture and molecular integrity. Multiplex immunofluorescence (mIF) using tyramide …

Histological and immunohistochemical characteristics of superficial peritoneal endometriotic lesions of clinical responders and non-responders to dienogest treatment.

Are there histological and immunohistochemical patterns of superficial peritoneal endometriotic lesions of symptomatic patients that characterize non-response to dienogest treatment and may suggest progesterone resistance?

Analgesic and Anti-Inflammatory Activity of Ambroxol in the Treatment of Endometriosis: An Experimental Study in Wistar Rats.

Background/Objective: This study evaluated the analgesic and anti-inflammatory effects of ambroxol in an experimental model of endometriosis. Methods: Ambroxol was administered at doses of 10, 50, and 100 mg/kg (Abx …

Pathogenesis of Adenomyosis: An Integrated Review of Cellular Origins, Molecular Mechanisms, and Intersecting Diseases.

Adenomyosis is a prevalent disorder of the archimetra, historically conflated with endometriosis but possessing a unique pathobiological trajectory. This review synthesises current molecular evidence to propose a unified mechanistic framework …

Endometrial NCOR1 deficiency contributes to implantation failure in endometriosis-associated infertility.

Endometriosis-associated infertility is a complex condition in which the presence of endometrial-like tissue disrupts implantation and early pregnancy. Epigenetic regulators are critical for implantation and decidualization, yet their contribution to …

Malignant Transformation of Endometriosis: A Rare Case of Extrauterine Endometrial Stromal Sarcoma.

Endometrial stromal sarcoma (ESS) is an extremely uncommon uterine malignancy, and commonly arises from preexisting endometriosis. On rare occasions, ESS arises from extrauterine tissues and is known as extra-uterine ESS. …

Thoracic endometriosis in an inoperable patient.

In this case report, we present a case of a woman in her 30s who was diagnosed with thoracic endometriosis presenting as a large pulmonary mass. Hormonal treatment progestin (synthetic …

Diaphragmatic endometriosis with hepatic herniation: case report and review of literature.

Diaphragmatic endometriosis is a rare and often underrecognized manifestation of extrapelvic endometriosis that may lead to severe complications such as diaphragmatic rupture or herniation. We report the case of a …

Evaluating Subtypes of Endometriosis in Rhesus Macaques (Macaca mulatta) Using Clinical Findings and Immunohistochemistry.

Endometriosis is defined as endometrial tissue outside of the uterus. It is a debilitating, complex, and underdiagnosed condition, impacting approximately 10%-15% of reproductive-aged women worldwide. Endometriosis is associated with chronic …