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Endometrial organoids to model benign disorders affecting the endometrium.

The endometrium is a highly dynamic and complex tissue lining the uterus, playing a central role in reproductive health. Despite its importance, the pathogenesis of many benign endometrial disorders remains …

Published: March 31, 2026, midnight
Synergistic effects of melatonin and dienogest on pain relief in endometriosis: a randomized controlled trial.

Endometriosis affects 5-10% of reproductive-aged women and is characterized by chronic pelvic pain, dysmenorrhea, dyspareunia, and infertility. Standard hormonal therapies, such as dienogest, effectively manage symptoms, but are often associated …

Published: March 31, 2026, midnight
Surgical management of ovarian endometrioma in a patient with fibrodysplasia ossificans progressiva: a case report.

Fibrodysplasia ossificans progressiva (FOP) is an ultra-rare (prevalence ~ 1:2 million), devastating genetic disorder characterized by progressive heterotopic ossification. Crucially, surgical trauma is a potent trigger for catastrophic new bone …

Published: March 31, 2026, midnight
Harnessing mangroves for epigenetic therapies.

Mangroves are valuable reservoirs of diverse phytochemicals with significant therapeutic potential. Beyond their ecological roles, these bioactive compounds can influence epigenetic mechanisms, heritable changes in gene expression without alterations in …

Published: March 30, 2026, midnight
Hypoxia-induced miR-21-5p promotes autophagy by downregulating CDC25A in endometriosis.

Endometriosis is a common gynecological disorder affecting women of reproductive age, often leading to chronic pain, reduced quality of life, and infertility. It is characterized by ectopic endometrial growth within …

Published: March 30, 2026, midnight
Regulatory Role of MRTF-A in Macrophage Polarization and the Therapeutic Mechanism of Bushen Wenyang Huayu Decoction in Endometriosis.

Traditional Chinese Medicine (TCM) offers multiple advantages in the treatment of endometriosis(EMS). Bushen Wenyang Huayu Decoction (BWHD) is widely used in clinical practice for managing EMS. It can significantly alleviate …

Published: March 30, 2026, midnight
Nanoceria as an Innovative Therapy for Endometriosis: Impact on Lesion Reduction and Therapeutic Optimization.

Endometriosis is a chronic inflammatory disease with limited therapeutic options and frequent adverse effects. This study aimed to develop and evaluate cerium oxide nanoparticles (nanoceria) as a potential therapeutic strategy …

Published: March 30, 2026, midnight
Surgically Relative Risk Factors for Lower Colorectal Anastomotic Dehiscence and Rectovaginal Fistulas in Complex Deep Endometriosis Cases: A Single-Center Retrospective-Prospective Cohort Study.

Background: Bowel surgery is a key component of advanced deep endometriosis management, with anastomotic leakage representing the most serious postoperative complication. This study aimed to identify risk factors for dehiscence …

Published: March 30, 2026, midnight
Demographic and hematological differences between endometriosis and menorrhagia in Saudi women: A retrospective observational study of 946 patients.

Endometriosis and menorrhagia are prevalent gynecological conditions with overlapping symptoms, yet comparative data from Middle Eastern populations remain scarce. We aimed to comprehensively characterize demographic and hematological differences between these …

Published: March 28, 2026, midnight
Shared Pathophysiology and Early Detection Biomarkers in Endometriosis and Polycystic Ovary Syndrome (PCOS): Opportunities for AI-Enabled Screening.

Endometriosis and polycystic ovary syndrome (PCOS) are common, multifactorial gynecological disorders shaped by endocrine imbalance, immune dysfunction, metabolic disruption, genetic susceptibility, and environmental exposures. Despite their major contribution to infertility …

Published: March 28, 2026, midnight
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