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The Estrogen-Immune Interface in Endometriosis.

Endometriosis is a gynecologic condition characterized by the growth of endometrium-like stroma and glandular elements outside of the uterine cavity. The involvement of hormonal dysregulation, specifically estrogen, is well established …

Published: Jan. 6, 2025, midnight
Time-series single-cell transcriptomic profiling of luteal-phase endometrium uncovers dynamic characteristics and its dysregulation in recurrent implantation failures - Nature.com

Time-series single-cell transcriptomic profiling of luteal-phase endometrium uncovers dynamic characteristics and its dysregulation in recurrent implantation failures Nature.com

Published: Jan. 3, 2025, 3:33 a.m.
Downregulated METTL3 Accumulates TERT Expression that Promote the Progression of Ovarian Endometriosis.

Endometriosis is a complicated and enigmatic disease that significantly diminishes the quality of life for women affected by this condition. Increased levels of human telomerase reverse transcriptase (TERT) mRNA and …

Published: Dec. 31, 2024, midnight
Nuclear Receptor Subfamily 4 Group A Member 3: A Potential Marker of Endometriosis.

Nuclear receptor subfamily 4 group A member 3 (NR4A3) is lowly expressed in ectopic endometrium and can be degraded by ubiquitination in vascular endothelial cells. Murine double minute 2 (MDM2) …

Published: Dec. 28, 2024, midnight
NAT10 drives endometriosis progression through acetylation and stabilization of TGFB1 mRNA.

Endometriosis, a gynecological disorder marked by pelvic pain and infertility, has its pathogenesis and pathophysiology significantly influenced by epigenetics, as these factors have been well characterized. However, the role of …

Published: Dec. 26, 2024, midnight
Ectopic endometrial stromal cell-derived extracellular vesicles encapsulating microRNA-25-3p induce endometrial collagen I deposition impairing decidualization in endometriosis.

Endometrial collagen I undergoes dynamic degradation and remodelling in response to endometrial stromal cell (ESC) decidualization and embryo implantation. However, excessive collagen I deposition in the endometrium during the implantation …

Published: Dec. 25, 2024, midnight
N6-methyladenosine methylation regulators can serve as potential biomarkers for endometriosis related infertility.

Endometriosis (EMS) is a chronic inflammatory disease frequently associated with infertility. N6-methyladenosine (m6A) methylation, the most common form of methylation in eukaryotic mRNAs, has gained attention in the study of …

Published: Dec. 25, 2024, midnight
Prospects for potential therapy targeting immune‑associated factors in endometriosis (Review).

Endometriosis (EM) is a chronic inflammatory disease that is one of the most common causes of gynecological systemic lesions in women before menopause. The most representative histological feature of EM …

Published: Dec. 24, 2024, midnight
[Mechanism of Luoshi Neiyi Formula in treatment of SF-1 on endometriosis by improving hypoxia].

This study investigated the effect of Luoshi Neiyi Formula(LSNYF) on hypoxia-inducible factor-1α(HIF-1α) and steroidogenic factor 1(SF-1) in endometriosis(EMs), aiming to explore the mechanism of Luoshi Neiyi Formula in treating EMs. …

Published: Dec. 21, 2024, midnight
Platelets as key cells in endometriosis patients: Insights from small extracellular vesicles in peritoneal fluid and endometriotic lesions analysis.

Endometriosis is a chronic inflammatory condition characterized by the presence of endometrium-like tissue outside the uterus, primarily affecting pelvic organs and tissues. In this study, we explored platelet activation in …

Published: Dec. 20, 2024, midnight
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