Hormonal therapies for endometriosis-associated pain: inflammatory limitations and pharmacological challenges.
Endometriosis is a chronic inflammatory and estrogen-dependent disease in which pain remains the leading cause of impaired quality of life. Hormonal therapies constitute the cornerstone of medical management and include …
Integrated lipidomics and transcriptomics reveal the key role of ceramides in the development of endometriosis.
Endometriosis (EMs) is a chronic gynecological disease with poorly understood pathogenesis. This study integrated lipidomics and transcriptomics to systematically investigate aberrant sphingolipid metabolism in EMs, aiming to identify pathogenic mechanisms …
Clinical Impact of HPV Self-Sampling and Molecular Biomarkers on Cervical Cancer Screening and Triage: "The Times They Are A-Changin'"-A Comprehensive Review and Future Perspectives.
Human papillomavirus (HPV) infection is a necessary but insufficient cause of cervical cancer (CC) and reflects a long-standing host-virus equilibrium shaped by immune control, viral persistence, and latency. The transition …