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Update on the pathogenesis of endometriosis-related infertility based on contemporary evidence.

Endometriosis, the most prevalent cause of infertility, is associated with anatomical distortion leading to adhesions and fibrosis, as well as endocrine abnormalities and immune disorders. This review discusses the mechanisms …

Published: March 10, 2025, midnight
Stem cell theory: A new horizon for the treatment of endometriosis by targeting mesenchymal stem cell.

Endometriosis is a prevalent chronic gynecological disease that poses significant challenges for treatment due to its extensive lesions, diverse morphology, unknown etiology, and tendency for recurrence. In the early 21st …

Published: March 7, 2025, midnight
Oxidative stress in endometriosis: Sources, mechanisms and therapeutic potential of antioxidants (Review).

Endometriosis affects ~15% of women of reproductive age worldwide, impacting ~190 million individuals. Despite its high prevalence, the precise pathogenesis of endometriosis remains unclear. Emerging evidence has highlighted oxidative stress …

Published: March 7, 2025, midnight
Identification and analysis of oxidative stress-related genes in endometriosis.

Early diagnosis and treatment of endometriosis (EM) remain challenging because of the lack of knowledge about EM development. While oxidative stress (OS) has been associated with EM, the link is …

Published: March 7, 2025, midnight
The Role of Mast Cells in the Development and Advancement of Endometriosis.

Endometriosis is a medical condition identified by the presence of endometrium-like tissue outside the uterus. This condition is known to result in symptoms such as frequent pelvic pain, infertility, and …

Published: March 4, 2025, 12:17 a.m.
GRB2 regulation of essential signaling pathways in the endometrium is critical for implantation and decidualization.

Over 75% of failed pregnancies involve implantation defects. Growth factor receptor-bound protein 2 (GRB2) is an adaptor protein involved in signal transduction and cell communication. Here we show that the …

Published: March 4, 2025, midnight
MCP-1 promotes ILK phosphorylation at Ser246 during endometriosis development and affects the pregnancy outcome.

In women with endometriosis, monocyte chemoattractant protein 1 (MCP-1) or chemokine (C-C motif) ligand 2 (CCL2) is elevated in serum, peritoneal fluid, and endometriotic lesions, though its exact role in …

Published: March 4, 2025, midnight
Maternal autoimmune diseases and the risk of tics and Tourette's disorder in offspring: insights from Taiwan's real-world data.

Currently, tics and Tourette's disorder are burdensome neurological disorders that manifest in vocal and motor tics with onset during childhood. Previous studies have demonstrated that maternal autoimmune diseases may cause …

Published: March 4, 2025, midnight
Vitamin D in Reproductive Health Disorders: A Narrative Review Focusing on Infertility, Endometriosis, and Polycystic Ovarian Syndrome.

Vitamin D (VD) is a fat-soluble steroid hormone with essential physiological functions beyond calcium and bone metabolism. In recent years, its role in women's reproductive health has gained attention, influencing …

Published: March 3, 2025, midnight
FOXA2 loss results in an increase of endometriosis development and LIF reveals a therapeutic effect for endometriosis.

Endometriosis, characterized by the growth of uterine-like tissue outside the uterus, causes chronic pain and infertility. Current diagnostic and therapeutic strategies have notable limitations, including delayed diagnosis and adverse effects. …

Published: March 2, 2025, 12:04 a.m.
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