Endometriosis is a common disease among women of childbearing age. However, the molecular mechanism behind it is still unknown. Therefore, new biomarkers and therapeutic targets are needed to improve the …
Lipedema is a chronic, estrogen-sensitive adipose tissue disorder characterized by disproportionate subcutaneous fat accumulation, fibrosis, inflammation, and resistance to fat mobilization. Despite its high prevalence, lipedema remains poorly understood and …
Endometriosis is a chronic gynecological pathology marked by the aberrant proliferation of tissue analogous to the endometrial lining outside the uterine cavity. This disorder frequently engenders persistent pelvic discomfort, infertility, …
Recent studies emphasize the role of immune dysregulation and inflammation in endometriosis (ES). While hormonal therapy remains the primary treatment, emerging research is exploring synergistic approaches that target inflammation. In …
This review explores the dual role of reactive oxygen species (ROS) and free radicals in the pathogenesis of endometriosis, aiming to deepen our understanding of these processes through a systematic …
The adenosine monophosphate (AMP)-activated protein kinase (AMPK) signalling pathway regulates cell metabolism, inflammation and the immune response. This signalling pathway is essential for maintaining reproductive homeostasis and influencing steroidogenesis, implantation, …
Endometriosis and endometrial polyps are oestrogen-dependent conditions that frequently co-occur, yet their combined prevalence remains unclear. This study synthesized data on the prevalence of endometrial polyps in women with endometriosis …
The Ras homolog gene family member A (RhoA) is a small GTPase. RhoA plays major roles in cytoskeletal regulation, transcriptional control, and cell cycle maintenance. RhoA is widely expressed in …
Patients with endometriosis often experience bowel symptoms such as changing stool, abdominal pain and bloating similar to those associated with irritable bowel syndrome. These symptoms reduce quality of life (QoL). …
Existing evidence shows the importance of circulating cytokines in studying female reproductive system dysfunction. Endometriosis (EM) is thought to be associated with multiple immune cytokines, but its causality has not …