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High-Resolution Spatial Transcriptomics Reveals Fibroblast and Neuroimmune Microenvironments in Endometriosis Lesions.

Endometriosis is a chronic, systemic, inflammatory disease characterized by the presence of endometrium-like tissue growing outside of the uterus. One of its main symptoms is chronic pain and inflammation leading …

Published: Aug. 25, 2025, midnight
MMP2/TIMP2 ratio as a measurable indicator for differentiating diffuse adenomyosis, ovarian endometriosis, and their co-existence.

Adenomyosis and endometriosis, two common estrogen-dependent benign gynecological disorders usually present with overlapping symptoms, such as pain and infertility. These two conditions often co-exist and are associated with poor reproductive …

Published: Aug. 24, 2025, midnight
3D map-guided modeling of functional endometrial tissue using multi-compartment assembloids.

The human endometrium is a dynamic tissue that lines the uterus and undergoes constant remodeling, making it especially susceptible to gynecological diseases like endometriosis and endometrial cancer. The molecular mechanisms …

Published: Aug. 23, 2025, midnight
Intestinal Endometriosis, A Challenge for Gastroenterologists: A Narrative Review.

Endometriosis is a medical condition where endometrial tissue and glands are found outside the uterine cavity: on ovaries, pelvic peritoneum, rectovaginal septum, bladder, bowel and more. The ectopic tissue is …

Published: Aug. 22, 2025, midnight
Genetic factors associated with the co-occurrence of endometriosis with antiphospholipid syndrome (Review).

Immune-related factors may serve an important role in the development of endometriosis, considering the occurrence of substantial abnormalities in the immune system of women with endometriosis, including reduced T-cell reactivity …

Published: Aug. 22, 2025, midnight
NR4A1 Acts as a Nutrient Sensor That Inhibits the Effects of Aging.

Orphan nuclear receptor 4A1 (NR4A1) is a member of the NR4A subfamily that was initially discovered as an intermediate early gene expressed in response to stressors, including inflammatory agents. This …

Published: Aug. 21, 2025, midnight
Toward Sex-Specific Biomaterials Innovation: A Perspective.

Sex-related differences influence key biological processes relevant to biomaterials research, including tissue regeneration, immune response, drug metabolism, and relevant diseases. Despite increasing recognition of sex as a critical biological variable, …

Published: Aug. 20, 2025, midnight
Nuck canal cyst: use of immunohistochemistry to reveal vestigial endometriosis hidden within mural granulation tissue.

A case of a Nuck canal cyst (NCC) associated with vestigial endometriosis is presented. An ultrasound scan revealed a multicystic sac in the right groin of a 42-year-old woman who …

Published: Aug. 20, 2025, midnight
Subclinical Leaflet Thrombosis and Subclinical Aortic Valve Complex Thrombosis in TAVR.

Subclinical leaflet thrombosis (SLT) following transcatheter aortic valve replacement occurs in 10% to 15% of patients at 1 month and up to 30% by 1 year, extending to perivalvular structures …

Published: Aug. 20, 2025, midnight
The secrets of menstrual blood: emerging frontiers from diagnostic tools to stem cell therapies.

Menstrual blood (MB), a biofluid rich in diverse cell types and biomolecules, has emerged as a vital resource for investigating female reproductive health and diseases because of its unique composition …

Published: Aug. 20, 2025, midnight
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