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Ovarian Endometrioma Disrupts Oocyte-Cumulus Communication and Mitochondrial Function, With Melatonin Mitigating the Effects.

Ovarian endometrioma (OEM), a particularly severe form of endometriosis, is an oestrogen-dependent condition often associated with pain and infertility. The mechanisms by which OEM impairs fertility, particularly through its direct …

Published: Jan. 21, 2025, midnight
A cRGD-modified liposome for targeted delivery of artesunate to inhibit angiogenesis in endometriosis.

Currently, hormonal therapy for endometriosis faces challenges in achieving a balance between treatment and preserving the chance of pregnancy. Therefore, the development of non-hormonal therapy holds significant clinical importance. Angiogenesis …

Published: Jan. 20, 2025, midnight
Evaluating the association between lipidome and female reproductive diseases through comprehensive Mendelian randomization analyses.

This study aimed to assess the causal relationship between lipidome and female reproductive diseases (FRDs) using an advanced series of Mendelian randomization (MR) methods. This study utilized genome-wide association study …

Published: Jan. 19, 2025, midnight
Comparison of ovarian reserve after laparoscopic cystectomy in patients with ovarian endometriosis differ in cyst size: A systematic review and meta-analysis.

Whether cyst size affects ovarian reserve before and after surgery remains controversial.

Published: Jan. 19, 2025, midnight
Hypomethylation of IL6ST promotes development of endometriosis by activating JAK2/STAT3 signaling pathway.

Endometriosis is a chronic inflammatory disorder characterized by presence of endometrial tissue outside the uterine cavity. Immunohistochemical analysis (IHC) revealed markedly elevated expression of IL6ST in endometrial tissue of patients …

Published: Jan. 16, 2025, midnight
Endometriosis does not impact aneuploidy rates of products of conception in IVF population.

It has been debated whether endometriosis (EMS) adversely affects oocyte quality, potentially leading to a higher incidence of genetically unbalanced embryos or other egg factors that affect the developmental potential. …

Published: Jan. 16, 2025, midnight
Malignant transformation of extragenital endometriosis.

Endometriosis is a chronic disease characterised by the presence of endometrial tissue outside the uterine cavity, affecting 5-15% of women, especially those of reproductive age. The disease may manifest itself …

Published: Jan. 14, 2025, midnight
Impact of deep or ovarian endometriosis on pelvic pain and quality of life: prospective cross-sectional ultrasound study.

To assess whether premenopausal women diagnosed with deep or ovarian endometriosis on transvaginal sonography (TVS) were more likely to suffer from dyspareunia and pelvic pain symptoms, and have a lower …

Published: Jan. 14, 2025, midnight
Polypoid endometriosis in a young female with systemic lupus erythematosus, mimicking ovarian and pelvic malignancy, a case report.

Polypoid endometriosis is a rare mass-like variant of endometriosis. Mass-like content with indistinct margins between the uterus and pelvic side wall mimics characteristics of pelvic malignancy. Systemic lupus erythematosus (SLE) …

Published: Jan. 12, 2025, midnight
Single-cell and spatial transcriptomic profiling revealed niche interactions sustaining growth of endometriotic lesions.

Endometriosis is a chronic condition with limited therapeutic options. The molecular aberrations promoting ectopic attachment and interactions with the local microenvironment sustaining lesion growth have been unclear, prohibiting development of …

Published: Jan. 11, 2025, midnight
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