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Molecular Pathogenesis of Ovarian Endometrioma: Mechanistic Insights and Therapeutic Implications.

Ovarian endometrioma (OMA), the most prevalent and clinically consequential subtype of endometriosis, represents a chronic inflammatory disorder characterized by ectopic endometrial-like lesions. This condition manifests as progressive dysmenorrhea, ovarian reserve …

Published: Oct. 4, 2025, midnight
The dual nature of immunotherapy in female reproductive disorders: immune homeostasis and clinical challenges.

The female reproductive system (FRS) exhibits unique immunological characteristics, balancing defense against pathogens with tolerance to sperm and semi-allogeneic embryos. Key players include decidual natural killer (dNK) cells, immune checkpoint …

Published: Oct. 2, 2025, midnight
Circulating microRNAs and Endometriosis: A Comprehensive Analysis and Validation of Identified Biomarkers in the Indian Population.

Endometriosis is a prevalent condition where tissue similar to the uterine lining grows outside the uterus, causing pain and infertility. Diagnosing endometriosis typically requires invasive procedures like laparoscopy. MicroRNAs (miRNAs) …

Published: Oct. 1, 2025, midnight
From biomolecules to breakthroughs: exosomes as next-generation theranostics in female infertility.

Female infertility and reproductive disorders represent a significant global health challenge, with complex etiologies often linked to impaired cellular communication, inflammation, and tissue dysfunction. Exosomes (EXOs), nanosized extracellular vesicles laden …

Published: Oct. 1, 2025, midnight
Reduced Vagal Tone in Women with Adenomyosis.

Adenomyosis is an estrogen-dependent disease featuring chronic inflammation. This study was undertaken to investigate whether the vagal tone is reduced in patients with adenomyosis as compared with healthy women. We …

Published: Sept. 30, 2025, midnight
Psychological factors mediate the relationship between trauma exposure and pain intensity in women with endometriosis: a cross-sectional study.

Endometriosis, a chronic inflammatory condition often characterized by chronic pelvic pain, significantly impacts women's quality of life. While psychological distress, including depression and anxiety, is prevalent in women with endometriosis, …

Published: Sept. 29, 2025, midnight
Erythema ab igne-A Potential Cutaneous Marker of Chronic Heat Use in Patients with Endometriosis: A Narrative Literature Review and a Case Report.

Erythema ab igne (EAI), also known as "hot water bottle rash" or "toasted skin syndrome", is a benign cutaneous condition caused by chronic exposure to low-level infrared heat. It typically …

Published: Sept. 29, 2025, midnight
Establishing an electronic patient-reported outcome (ePRO) for patients with endometriosis and chronic pelvic pain: A pilot feasibility study.

Endometriosis and chronic pelvic pain (CPP) are complex conditions that significantly impact quality of life. Few tools systematically capture patient-reported outcomes in this population. This pilot study evaluated patients' experiences …

Published: Sept. 29, 2025, midnight
Resection of Bilateral Endometriosis of the Uterosacral Ligaments Resolves Voiding Dysfunction: A Case Report.

Patients with deep endometriosis of the posterior pelvic compartment might present various lower urinary tract symptoms, including urinary retention, without any prior pelvic surgery in their medical history. These symptoms, …

Published: Sept. 29, 2025, midnight
FIGO committee opinion: Environmental drivers of gynecologic and reproductive health.

This FIGO committee opinion paper addresses the growing body of evidence linking environmental exposures to common gynecologic and reproductive conditions across the life course. From adolescence through menopause, women are …

Published: Sept. 26, 2025, midnight
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