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Retrospective evaluation of the mr#ENZIAN classification's applicability in the pre-operative assessment of complex endometriosis: a compartment-dependent challenge.

Pelvic MRI is increasingly performed as a second-line investigation in suspected complex cases of endometriosis, to precisely localize lesions and to optimise surgical planning. To facilitate MRI evaluation and inter-disciplinary …

Published: March 9, 2026, midnight
Advanced Management of Severe Adenomyosis in IVF: A Personalized Approach With Extended GnRH Agonist and Letrozole Therapy.

The objective of this study is to evaluate the effectiveness of prolonged GnRH agonist (GnRH-a) suppression combined with letrozole and intensive luteal phase support in a patient with severe adenomyosis …

Published: March 9, 2026, midnight
Endometriosis at the Single-Cell Level: Molecular Insights and Implications for Assisted Reproduction Success.

Endometriosis is a chronic hormone-responsive disorder linked to infertility, usually characterized by the presence of ectopic endometrium in the pelvis that disrupts local homeostasis. Advances in single-cell "omic" methods have …

Published: March 9, 2026, midnight
The effect of endometriosis on fertility: Results of the National Health and Nutrition Examination and Mendelian randomization analysis, 1999 to 2006.

This study aims to investigate the effect of endometriosis (EMs) on fertility and to assess the causal relationship between EMs and fertility using two-sample Mendelian randomization (MR). We conducted an …

Published: March 7, 2026, midnight
Lactoferrin as a Non-Hormonal Therapeutic Candidate for Endometriosis: Mechanisms and Future Directions.

The pathogenesis and progression of endometriosis may involve a complex combination of multiple factors, including chronic inflammation and oxidative stress. Hormonal therapy, the current standard for pharmacotherapy in endometriosis, causes …

Published: March 5, 2026, midnight
Why does surgery for endometriosis-associated infertility often fail to improve pregnancy outcome?

Endometriosis can impair natural reproduction through multiple mechanisms, including distortion of pelvic anatomy and chronic peritoneal inflammation. On this basis, surgical treatment might be reasonably expected to benefit. However, clinical …

Published: March 5, 2026, midnight
Comparison Between Catheter-Directed Sclerotherapy and Surgical Removal of Large Ovarian Endometriomas: A Retrospective, Single-Center Observational Study.

Background/Objectives: The treatment options for endometriosis vary depending on individual needs and clinical circumstances. To preserve ovarian reserve, ethanol catheter-directed sclerotherapy may be considered as a treatment option. We compared …

Published: March 4, 2026, midnight
AI-based BRAIx risk score for the intermediate-term prediction of breast cancer: a population cohort study.

Artificial intelligence (AI)-based algorithms are being implemented in breast screening to detect breast cancers on mammographic images. We aimed to apply an epidemiological approach to demonstrate how a cancer detection …

Published: March 3, 2026, midnight
Next-Generation Dietary Antioxidants in Women's Reproductive Health: Mechanisms, Reproductive Outcomes, and Therapeutic Potential.

Oxidative stress has emerged as a key factor regulating female fertility, reproductive aging, and the development of various gynecologic and pregnancy-associated diseases. While physiological concentrations of reactive oxygen species play …

Published: March 3, 2026, midnight
Engineering the Human Endometrial-Embryo Interface: Breakthroughs in 3D Uterine Models.

Three-dimensional (3D) organoid and co-culture models have emerged as transformative tools for studying human endometrial function, implantation, and placental development, overcoming key limitations of animal and two-dimensional in vitro systems. …

Published: March 3, 2026, midnight
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