Endometriosis is a chronic inflammatory disorder that affects 5-15% of women of reproductive age. It is characterized by severe symptoms, including dysmenorrhea and non-cyclic pelvic pain, which can substantially impair …
The "gut microbiota-mitochondria axis" has become the core hub connecting the metabolism, immunity, and endocrine regulation of gynecological diseases. In this review, the hierarchical regulation mechanism of this axis is …
Endometriosis, affecting approximately 10% of reproductive-aged women worldwide, is widely recognized as a chronic inflammatory disease. Inflammation-related genes (IRGs) play a crucial role in the occurrence and progression of various …
Endometriosis (EMs) is one of the most common gynecologic diseases, and the roles of ferroptosis in EMs have not been fully clarified. The induction of ferroptosis has been demonstrated to …
Patient-derived organoids (PDOs) have emerged as physiologically relevant three-dimensional (3D) culture systems that closely mimic the molecular and histological features of the human endometrium and associated malignancies. Owing to their …
Lactic acid modification of histones represents an emerging post-translational modification that establishes a critical link between cellular metabolic reprogramming and epigenetic regulation through the covalent binding of lactic acid to …
Gynecological diseases, such as polycystic ovary syndrome (PCOS) and endometriosis, are prevalent global health concerns. Conventional diagnostics often rely on invasive procedures or costly imaging, limiting accessibility in resource-constrained settings. …
Mineralocorticoid receptor antagonists, spironolactone, eplerenone, and finerenone, are cornerstone therapies in cardiovascular and renal diseases. While their efficacy is established, a systematic, head-to-head comparison of their post-marketing safety profiles based …
The gut microbiota plays a crucial function in reproductive well-being and is vital for maintaining fundamental physiological balance. This article surveys the mutual relationships between the gut flora and the …
The appendix is involved in a diverse spectrum of inflammatory, infectious, benign, and malignant conditions that extend far beyond acute appendicitis. Although acute appendicitis remains the most common appendiceal emergency, …