Multiple lesion inductions intensify central sensitization driven by neuroinflammation in a mouse model of endometriosis.
Endometriosis is an inflammatory disease associated with chronic pelvic pain (CPP). Growing evidence indicates that endometriotic lesions are not the sole source of pain. Instead, central nervous system (CNS) dysfunction …
RNA sequencing reveals novel molecular mechanisms of endometriosis lesion development in a mouse model.
Understanding of molecular mechanisms contributing to the pathophysiology of endometriosis, and upstream drivers of lesion formation, remains limited. Using a C57Bl/6 mouse model in which decidualized endometrial tissue is injected …