Endometriosis is an estrogen-dependent inflammatory disorder that may be influenced by bisphenol A (BPA), an endocrine-disrupting chemical commonly found in food-contact plastics. BPA has been implicated in altered steroidogenesis, immune …
Endometrosis is a chronic degenerative condition of the mare endometrium characterized by progressive fibrosis and glandular alterations that impair uterine function and fertility. Its pathogenesis involves persistent inflammation, the activation …
Endometriosis is a chronic condition in which tissue similar to the lining of the uterus grows in other parts of the body. It affects roughly 1 in 10 women of …
In 2024, the National Academies of Sciences, Engineering, and Medicine (NASEM) published a report entitled Advancing Research on Chronic Conditions in Women. A major purpose of this report was to …
Endometrial dysfunction represents a central pathological factor underlying recurrent implantation failure and infertility. This review provides a comprehensive synthesis of the physiological basis of endometrial function, the pathological factors compromising …
Lactate is increasingly recognized not only as a metabolic end product of glycolysis but also as a signaling metabolite that links metabolic reprogramming to epigenetic and transcriptional regulation through protein …
The female reproductive tract (FRT), particularly the vagina, has traditionally been regarded as a sterile environment. However, it is now recognized that the vagina is a complex, dynamic ecosystem dominated …
To compare embryo euploidy rates and reproductive outcomes among women with ovarian endometriomas who underwent ethanol sclerotherapy (EST), laparoscopic cystectomy, or expectant management prior to in vitro fertilization (IVF) with …
Endometriosis is a chronic inflammatory disease with cancer-like features, yet the mechanisms linking metabolic dysregulation to immune remodeling during lesion progression remain poorly understood. Here, we identify the ubiquitin E3 …
A trend toward comorbid conditions is seen in around 50% of gynecological patients, with a significant contribution made by endometriosis as a common and incurable gynecological condition. Over the last …