Latest Articles

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Leveraging menstrual effluent (ME) to investigate vitamin D and human decidualization, a potential link with fertility.

Low vitamin D levels have been associated with female infertility, but the underlying mechanisms are not understood.

Published: Jan. 5, 2026, midnight
Honghua Ruyi Pill, a compound herbal medicine, improves endometriosis-related dysmenorrhea: A multicenter randomized, double-blind, placebo-controlled trial.

Endometriosis is an estrogen-dependent, progesterone-resistant gynecological disorder, with dysmenorrhea being the most common manifestation.

Published: Dec. 29, 2025, midnight
Immunological Causes of Infertility: Diagnostic Perspectives.

From an immunological perspective, infertility mechanisms encompass not only fertilization but also implantation, as well as both early and late pregnancy loss. Growing attention is being directed towards the influence …

Published: Dec. 25, 2025, midnight
Endometriosis and the Hallmarks of Cancer.

Endometriosis (EMS) is a non-cancerous invasive condition where tissue resembling the lining of the uterus is found outside of the uterine cavity. Endometriotic lesions have been found in nearly every …

Published: Dec. 23, 2025, midnight
Delayed onset of HPV-associated uterine malignancies: seven pathogenetic factors in contrast to cervical cancer.

Human papillomavirus (HPV) is a well-established etiological agent for cervical cancer, yet its contribution to endometrial malignancies remains underrecognized and mechanistically distinct. This paper synthesizes current evidence to explain the …

Published: Dec. 13, 2025, midnight
Progestins - a review of clinical application in gynecology.

Progestins are a group of substances with a wide range of applications. They are classified into pregnanes, estranes, and gonanes, and further divided into four generations based on their testosterone …

Published: Dec. 12, 2025, midnight
Transcriptional coregulator ZMIZ1 modulates estrogen responses that are essential for healthy endometrial function.

Estrogen is a critical regulator of endometrial health. Aberrant estrogen stimulation can result in infertility, endometrial cancer, and endometriosis. Here, we identified Zinc Finger MIZ-Type Containing 1 (Zmiz1) as a …

Published: Dec. 1, 2025, midnight
From Mice to Primates: Assessing Hormone-Based Endometriosis Models for Preclinical and Therapeutic Insights.

Endometriosis, a complex gynecological disorder characterized by ectopic endometrial-like tissue, affects over 10% of women, causing chronic pain and infertility. Despite extensive research, its pathophysiology remains incompletely understood, with proposed …

Published: Dec. 1, 2025, midnight
A Unique Case Series of Endometrial Vascular Dystrophy: Rising Incidence and Association With Uterine Pathologies.

Endometrial vascular dystrophy (EVD) is a rare hysteroscopic finding characterized by abnormal, tortuous, and dilated endometrial vessels, most often associated with abnormal uterine bleeding (AUB). Despite its potential clinical impact, …

Published: Nov. 24, 2025, midnight
Progesterone and IL-6 Expression Are Modulated by Follicular Fluid in Granulosa Cell Cultures.

Endometriosis (ENDO) and poor ovarian response (POR) represent challenging conditions in assisted reproduction. Both, associated with altered follicular fluid (FF) composition, specifically impact on granulosa cell (GC) function in an …

Published: Nov. 23, 2025, midnight
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