Infertility affects one in six individuals worldwide despite the advancement of assisted reproductive technologies. Successful embryo implantation is the first step of pregnancy, which relies on the establishment of a …
Decidualization of human endometrial stromal cells (ESCs) precedes the successful implantation of a human embryo. Improper decidualization has been reported in numerous conditions associated with infertility including endometriosis. Multiple pathways, …
Endometriosis is a chronic inflammatory disorder that significantly compromises women's health, typically manifesting as pelvic pain and/or infertility. This condition imposes a substantial burden on global healthcare systems.
Endometriosis is a chronic, estrogen-dependent inflammatory disorder affecting ~10% of reproductive-age women. It is underdiagnosed, with delays of 5-12 years. Symptoms include dysmenorrhea, chronic pelvic pain, dyspareunia, dyschezia, dysuria, fatigue, …
Endometriosis is a chronic hormone-responsive disorder linked to infertility, usually characterized by the presence of ectopic endometrium in the pelvis that disrupts local homeostasis. Advances in single-cell "omic" methods have …
Patients with endometriosis have greater risk of infertility, which is associated with compromised ovarian function. Dysfunction in follicular granulosa cells and hyperactivation of oestrogen receptor beta (ERβ) are evident in …
Accessory Cavitated Uterine Malformation (ACUM) can be misdiagnosed as other uterine pathologies, such as Müllerian anomalies, adenomyosis, or fibroids. In the present case series, we report on data of eleven …
Endometriosis is a common gynecological disease associated with pelvic pain and infertility. Despite several existing theories, the etiology and molecular mechanisms of endometriosis remain to be investigated. Here we report …
Endometriosis can impair natural reproduction through multiple mechanisms, including distortion of pelvic anatomy and chronic peritoneal inflammation. On this basis, surgical treatment might be reasonably expected to benefit. However, clinical …
Oxidative stress has emerged as a key factor regulating female fertility, reproductive aging, and the development of various gynecologic and pregnancy-associated diseases. While physiological concentrations of reactive oxygen species play …