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The role of mitochondrial DNA copy number in female infertility: a bidirectional two-sample Mendelian randomization study.

Previous studies on the impact of mitochondrial DNA (mtDNA) copy number on female infertility were limited and inconsistent.

Published: Dec. 23, 2024, midnight
Evaluating Lipiodol Efficacy in Proximal Tubal Occlusion Treatment: Single-Center Experience and Literature Review.

BACKGROUND Tubal infertility caused by proximal occlusion of fallopian tubes is a common cause of female infertility. Lipiodol (ethiodized oil) is an oil-based iodinated contrast medium, previously used in hysterosalpingography, …

Published: Dec. 10, 2024, midnight
Causal Relationship Between Endometriosis, Female Infertility, and Primary Ovarian Failure Through Bidirectional Mendelian Randomization.

Endometriosis and its associated gynecological diseases such as female infertility and primary ovarian failure (POF), impose a long-term disease burden on women. This study aims to explore the causal relationships …

Published: Dec. 9, 2024, midnight
The Pivotal role of hysteroscopy in diagnosing subtle uterine lesions in infertile patients: Seeing the unseen can make the difference.

Subtle uterine lesions are abnormal intracavitary conditions that, while not causing significant anatomical changes, can adversely impact fertility. Identifying these "subtle" lesions is challenging due to arbitrary interpretation, varied management …

Published: Dec. 9, 2024, midnight
MicroRNAs as Biomarkers and Therapeutic Targets in Female Infertility.

The study of microRNAs (miRNAs) has emerged in recent decades as a key approach to understanding the pathophysiology of many diseases, exploring their potential role as biomarkers, and testing their …

Published: Dec. 3, 2024, midnight
Multi-locus high-risk alleles association from interleukin's genes with female infertility and certain comorbidities.

Objective There is evidence that cytokine genes' single nucleotide polymorphisms could be the reasons behind female infertility. This study aimed to identify the role for Interleukin33 rs1048274 (G > A) …

Published: Nov. 23, 2024, midnight
Causal Link between Gut Microbiota and Infertility: A Two-sample Bidirectional Mendelian Randomization Study.

To investigate the associations of the gut microbiota with reproductive system diseases, including female infertility, male infertility, polycystic ovary syndrome (PCOS), primary ovarian failure, endometriosis, uterine fibroids, uterine polyps, sexual …

Published: Nov. 18, 2024, midnight
Upregulated let-7 expression in the follicular fluid of patients with endometriomas leads to dysfunction of granulosa cells through targeting of IGF1R.

What molecular mechanisms underlie the decline in ovarian reserve as the number and quality of oocytes decrease in patients with ovarian endometriomas (OEM)?

Published: Nov. 9, 2024, midnight
Investigating the metabolomic pathways in female reproductive endocrine disorders: a Mendelian randomization study.

Reproductive endocrine disorders (RED), including polycystic ovary syndrome (PCOS), endometriosis (EMs), and female infertility (FI), significantly affect women's health globally, with varying prevalence across different regions. These conditions can be …

Published: Oct. 31, 2024, midnight
N-acetylcysteine Clinical Applications.

This study aims to evaluate the therapeutic application of N-acetylcysteine (NAC) as a treatment or adjunct therapy for various medical conditions. While its efficacy in treating acetaminophen overdose, cystic fibrosis, …

Published: Oct. 24, 2024, midnight
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