Disruption of primary ciliary prostaglandin E2 signaling by transforming growth factor-β1 impairs endometrial receptivity.
Infertility affects one in six individuals worldwide despite the advancement of assisted reproductive technologies. Successful embryo implantation is the first step of pregnancy, which relies on the establishment of a …
Endometriosis at the Single-Cell Level: Molecular Insights and Implications for Assisted Reproduction Success.
Endometriosis is a chronic hormone-responsive disorder linked to infertility, usually characterized by the presence of ectopic endometrium in the pelvis that disrupts local homeostasis. Advances in single-cell "omic" methods have …
Why does surgery for endometriosis-associated infertility often fail to improve pregnancy outcome?
Endometriosis can impair natural reproduction through multiple mechanisms, including distortion of pelvic anatomy and chronic peritoneal inflammation. On this basis, surgical treatment might be reasonably expected to benefit. However, clinical …